Polysulfated Glycoaminoglycan Sterile Injection
Adequan I.M. - Luitpold Pharmaceuticals is recommended for the intramuscular treatment of non-infectious
degenerative and/or traumatic joint dysfunction and associated lameness of
the carpal and hock joints in horses. It stimulates the natural joint
repair process within 2 hours of the first injection.
Adequan I.M. inhibits harmful enzymes that attack the synovial fluid and cartilage
while stimulating cartilage repair. The health of the cartilage is critical
to the performance of the joint. Adequan i.m is complete FDA-
approved one-horse treatment regimen per package of 7 vials. Also available
in a multi-dose 50 ml vial.
milliliters of Adequan i.m. contains 500 mg of Polysulfated
Glycosaminoglycan and Water for Injection q.s. Sodium Hydroxide and/or
Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be
added to adjust tonicity. Improves carpal flexion by 71%. Improves synovial
fluid protein by 83%.
Glycosaminoglycan is chemically similar to the glycosaminoglycans in
articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor
and diminishes or reverses the pathologic recesses of traumatic or
degenerative joint disease which result in a net loss of cartilage matrix
components. PSGAG improves joint function by reducing synovial fluid protein
levels and increasing synovial fluid Hyaluronic acid concentration in
traumatized equine carpal and hock joints.
studies were conducted in horses. Doses as high as 2,500 mg were
administered intramuscularly to 6 horses twice a week for 12 weeks. This
dosage is 5 times the recommended dosage and 3 times the recommended
therapeutic regimen. Clinical observations revealed no o redness or swelling
at the injection site or in the affected joint. No animal had any clinical
or laboratory evidence of toxicity.
There are no
known contraindications to the use of intramuscular Polysulfated
Not for use
in horses intended for food.
recommended dose of Adequan i.m. in horses is 500 mg every 4 days for 28
days intramuscularly. The injection site must be thoroughly cleansed prior
to injection. Do not mix Adequan i.m. with other drugs or solvents.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
not been conducted to establish safety in breeding horses.
spent needles in accordance with all federal, state and local environmental
Keep this and
all medications out of the reach of children.
solution, 500 mg/5 mL is available in 5 mL glass vials, packaged in boxes of
7 ,and Multi-Dose 50 ml vial
controlled room temperature 18°-25°C (64°-77°F). Discard unused portion.