Allopurinol is used to reduce uric acid in dogs, cats and birds. It is given as a prophylactic treatment of recurrent uric acid uroliths and hyperuricosuric calcium
oxalate uroliths in small animals. It has also been used in an attempt to treat gout in pet
Allopurinol has also been recommended as an alternative
treatment for canine Leishmaniasis. Although it appears to have clinical efficacy, it does not
apparently clear the parasite in most dogs at usual dosages. Allopurinol may also be useful for
Allopurinol and its metabolite, oxypurinol, inhibit the enzyme xanthine oxidase. Xanthine oxidase is responsible for the conversion of oxypurines to uric acid. Hepatic microsomal enzymes may also be inhibited by
Dosage and Administration:
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