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Denosyl SD4 ® Denosyl SD4 protects liver cells from cell death and is helpful in cell repair and healing.  Denosyl SD4 elevates liver glutathione, the liver's main detoxifier, as well as supports overall liver health. Liver Problem + Denosyl SD4 = Healthier Liver

Denosyl SD4 (S-adenosylmethionine) is a nutritional supplement for use to aid in managing a variety of liver problems in dogs and cats.  Possible applications of Denosyl SD4 as adjunct therapy could include dogs and cats with elevated liver enzymes and suffering from: hepatic lipidosis, breed-specific chronic hepatitis, feline liver disease, Cushing's Disease, Inflammatory Bowel Disease, Pancreatitis, etc.

Denosyl SD4 is available in two sizes: 30 tablets, 90 mg each for cats and small dogs and  30 tablets, 225 mg each for dogs over 25 lbs.

• Denosyl SD4, a pure, patented, uniform, bioavailable, and stable salt of S-Adenosylmethionine
• The only S-Adenosylmethionine brand studied in U.S. veterinary trials
• Manufactured to Good Manufacturing Practice (GMP) standards
• Enteric coated and blister packed tablets to avoid exposure to air
• Supplied by the manufacturers of Cosequin®

Denosyl SD4 has been shown to increase hepatic glutathione levels in cats and dogs.  Glutathione, a potent antioxidant, is the liver's main detoxifier that protects hepatic cells from toxins and death. A recent analysis of 31 dogs and cats with various severe liver problems showed that 45% of these animals had low hepatic glutathione levels. Denosyl SD4 is recommended to improve hepatic glutathione levels in compromised patients to help maintain and protect liver function. Denosyl SD4 may also be used in other conditions of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations.

Administration as a Dietary Supplement: Because the tablet must be kept intact to prevent destruction by stomach acid, administration utilizes a dosage range, based on the nearest whole-tablet dose. The chart below is provided as a guide for administration. Daily dosage may also be calculated, based on 18 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. When giving more than one tablet, the total daily dose may be provided as a morning and evening dose. For example, a daily dose of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Feline and Canine Denosyl SD4 Administration Guide:

Body weight		Total daily administration and tablet size
Up to 12 pounds (5.5 kg)		One tablet of 90 mg
12 to 25 pounds (5.5-11 kg)		Two tablets of 90 mg
25 to 35 pounds (11 -16 kg)		One tablet of 225 mg
35 to 65 pounds (16 - 29.5 kg)		Two tablets of 225 mg
Over 65 pounds (29.5 kg +)		Three tablets of 225 mg
The number of tablets can be gradually reduced or may be increased at any time depending on the pet's needs.

Denosyl SD4 is the patented, pure and stabilized 1,4-butanedisulfonate salt of S-Adenosylmethionine. It is the only brand of S-Adenosylmethionine researched in U.S. trials for veterinary use in dogs and cats. Denosyl SD4 is available in two strengths: as an enteric coated 90 mg and 225mg tablet of active S-Adenosylmethionine. 

Storage: Store in a cool dry place. Because S-Adenosylmethionine is extremely hygroscopic, tablets are individually sealed in foil blister packs.  Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.  

Product Information Provided by NutraMax.  © NutraMax