Contraindications: Animal reproductive studies have shown
that furosemide may cause fetal abnormality and the drug is
contraindicated in pregnant animals. Furosemide is contraindicated
in anuria, furosemide hypersensitivity, hepatic coma, or during
electrolytic imbalances. Monitor serum electrolytes, BUN and CO2
frequently. Monitor serum potassium levels and watch for signs of
Corticosteroids cause an additive potassium-depletion effect.
Precautions: Disal Tablets are a highly effective
diuretic-saluretic which, if given in excessive amounts, may result
in dehydration and electrolyte imbalance. Therefore, the dosage and
schedule may have to be adjusted to the patient's needs. The animal
should be observed for early signs of electrolyte imbalance, and
corrective measures administered. Early signs of electrolyte
imbalance are increased thirst, lethargy, drowsiness or
restlessness, fatigue, oliguria, gastro-intestinal disturbances and
tachycardia. Special attention should be given to potassium levels.
Disal Tablets may lower serum calcium levels and cause tetany in
rare cases of animals having an existing hypocalcemic tendency.7
8 9 10 11
Disal Tablets are contraindicated in anuria. Therapy should be
discontinued in cases of progressive renal disease if increasing
azotemia and oliguria occur during the treatment. Sudden alterations
of fluid and electrolyte imbalance in an animal with cirrhosis may
precipitate hepatic coma, therefore observation during period of
therapy is necessary. In hepatic coma and in states of electrolyte
depletion, therapy should not be instituted until the basic
condition is improved or corrected. Potassium supplementation may be
necessary in cases routinely treated with potassium-depleting
steroids. Active or latent diabetes may on rare occasions be
exacerbated by furosemide. Transient loss of auditory capacity has
been experimentally produced in cats following intravenous
injections of excessive doses of furosemide at a very rapid rate.
Warnings: Disal Tablets are a highly effective diuretic
and, if given in excessive amounts, as with any diuretic, may lead
to excessive diuresis which could result in electrolyte imbalance,
dehydration and reduction of plasma volume, enhancing the risk of
circulatory collapse, thrombosis and embolism. Therefore, the animal
should be observed for early signs of fluid depletion with
electrolyte imbalance, and corrective measures administered.
Excessive loss of potassium in patients receiving digitalis or its
glycosides may precipitate digitalis toxicity. Caution should be
exercised in animals administered potassium-depleting steroids.
Correct potassium deficiency with proper dietary supplementation. If
animal needs potassium supplements, use oral liquid form, do not use
enteric-coated potassium tablets.
The concurrent use of furosemide with some antibiotics may be
inadvisable. There is evidence that the drug enhances the
nephrotoxic potential of aminoglycosides, cephalosporins and
polymyxins and increases the ototoxic effects of all aminoglycosides.
Sulfonamide diuretics have been reported to decrease arterial
responsiveness to pressor amines and to enhance the effect of
tubocurarine. Caution should be exercised in administering curare or
its derivatives to patients undergoing therapy with Disal Tablets
and it is advisable to discontinue Disal Tablets for one day prior
to any elective surgery.