Sentinel (milbemycin/lufenuron)
Flavor Tabs for Dogs
Sentinel is an oral heartworm
preventative, broad-spectrum anthelmintic
and flea control product for dogs.
Description and Composition
Oral tablets of 4 strengths are
available:
-
SENTINEL 2.3mg/46mg, a
tablet containing 2.3 mg of
milbemycin oxime and 46 mg of
lufenuron.
-
SENTINEL 5.75mg/115mg, a
tablet containing 5.75 mg of
milbemycin oxime and 115mg of
lufenuron.
-
SENTINEL 11.5mg/230mg, a
tablet containing 11.5 mg of
milbemycin oxime and 230 mg of
lufenuron.
-
SENTINEL 23mg/460mg, a
tablet containing 23 mg of milbemycin oxime and 460 mg of
lufenuron.
Properties
SENTINEL Flavor Tabs
contains the active ingredients
milbemycin oxime and lufenuron and
is basically a combination of
INTERCEPTOR and
PROGRAM
in each tablet.
Milbemycin oxime is a mixture of
the macrolides milbemycin A3 oxime
and milbemycin A4 oxime. Milbemycin
oxime is active against nematodes
and arthropods. Like other
macrolides, milbemycin oxime
interacts with the GABA receptors of
the nervous system.
Lufenuron is an insect growth
regulator belonging to the group of
benzoyl-phenyl-ureas (BPUs) and is
classified as an insect development
inhibitor (IDI). Like all BPU's,
lufenuron acts as a chitin synthesis
inhibitor. Treated immature fleas
will not be able to molt to the next
stage and females feeding on treated
animals will produce eggs out of
which no larvae will hatch. The
interruption of the flea life cycle
at various levels results in a
long-term very effective flea
control on the animal as well as in
the environment.
SENTINEL is well tolerated by
dogs of all ages and breeds,
including Collie breeds and breeding
animals.
Indications
SENTINEL is an oral tablet for
the prevention and control of flea
populations, the prevention of
heartworm (Dirofilaria immitis)
disease and the treatment and
control of roundworms (Toxocara
canis, Toxascaris leonina),
hookworms (Ancylostoma caninum)
and whipworms (Trichuris vulpis)
in dogs.
Dosage and Administration
SENTINEL is given orally with a meal
at the minimal dose of 0.5 mg
milbemycin oxime and 10mg lufenuron
per kg body weight according to the
following table:
|
Weight of dog |
Tablet
|
|
2 to 10 lbs |
1 tablet of
SENTINEL 2.3mg /46mg |
|
11-25 lbs |
1 tablet of
SENTINEL 5.75mg/115mg |
|
26 to 50 lbs |
1 tablet of
SENTINEL 11.5mg/230mg |
|
Over 51 lbs |
1 tablet of
SENTINEL 23mg/460mg |
Dogs over 45 kg are given an
appropriate combination of tablets.
SENTINEL must be given at monthly
intervals, preferably on the same
date starting within 1 month of the
begin of the transmission season and
continuing until 1 dose after its
end. Where heartworm transmission is
not seasonal SENTINEL is given
throughout the year. Dogs living in
heartworm-free regions and
traveling to heartworm risk areas
should be treated within 1 month of
the beginning of the exposure to
transmission. If necessary
administrations should be repeated
monthly until 1 administration after
the end of the exposure risk. If
SENTINEL replaces another heartworm
prevention the first dose should be
given within 1 month after the
previous treatment. The tablets can
be given directly into the mouth of
the dog or they can be given in a
portion of food.
For flea control, treatment of
existing infestations can begin at
any time. In cases of severe
infestations the use of an
adulticide like
CAPSTAR during the first few
weeks of the treatment may be
necessary.
For prevention of flea
infestations, treatment should
commence in spring, before the
beginning of the flea season, and
continued monthly throughout the
season.
For flea control, all dogs and
cats in a household must be treated
in order to prevent the build up of
developing fleas in the environment,
thus establishing an infestation.
For cats use
PROGRAM Oral Suspension
or
PROGRAM Flavor Tabs.
SENTINEL must be administered
with a meal. It can be given with a
small quantity of food before the
rest of the meal is given, or per os
immediately after feeding.
Special Precautions and
Warnings
Dogs should be tested for
heartworm infection. Heartworm
prevention programs should be
started only in dogs found to be
uninfected.
Formulations and Packages
There are 4 tablet strengths in
color-coded packs:
-
SENTINEL containing 2.3 mg
milbemycin oxime and 46 mg
lufenuron, in red packs.
-
SENTINEL containing 5.75 mg
milbemycin oxime and 15 mg
lufenuron, in green packs.
-
SENTINEL containing 11.5 mg
milbemycin oxime and 230 mg
lufenuron, in yellow packs.
-
SENTINEL containing 23 mg
milbemycin oxime and 460 mg
lufenuron, in white packs.
All 4 tablet sizes are available
in the same 2 packs:
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