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Synotic Otic Solution, 8 ml

Synotic Otic Solution, 8 ml


 
Sold ONLY to licensed veterinarians and pharmacies. Submit license if not already on file. Fax :: 800-640-3274
Licensed Professional Price: $13.17
Rx:
Copy of License Required [No Prescriptions Please]
NDC: 0856-0120-06

Stock Status:In Stock

Product Code: 10464
Qty:

Description
 

Synotic Otic Solution

Anti-Inflammatory Ear Medication

Synotic Otic Solution is indicated for the relief of pruritus and inflammation associated with acute and chronic otitis in the dog. Synotic is an otic corticosteroid in combination with DMSO for an enhanced anti-inflammatory effect.

Active Ingredients per each ml: Fluocinolone Acetonide 0.01% And Dimethyl Sulfoxide 60%

Dimethyl sulfoxide (DMSO) enhances the percutaneous absorption of medications.

Propylene glycol is well established as being nonsensitizing, nontoxic and has antimicrobial activity. It has been selected for this formulation because of several useful properties: There is a low surface tension permitting spreadability and penetration; its drying properties make it valuable in moist areas; the corticosteroid is highly soluble and stable in this vehicle; and a relatively slow rate of evaporation maintains the solution state for an adequate time to allow distribution and contact with all parts of the ear.

Fluocinolone acetonide is chemically related to prednisolone and possesses marked anti-inflammatory properties when applied topically. It has been shown to have over 100 times the anti-inflammatory activity of hydrocortisone. Fluocinolone acetonide decreases edema, inflammation, erythema, infiltration and pruritus with its associated scratching and excoriation.

Dosage and Administration: The recommended dose of Synotic Otic Solution Veterinary is 4 to 6 drops (0.2 mL) per ear administered twice daily into the ear canal for a maximum period of 14 days. The total dosage used should not exceed 17 mL. It is recommended that the affected ear canal be cleansed by some appropriate method prior to the instillation of the solution. Following instillation, gentle external massage of the ear canal may aid in promoting an even distribution of the medication. Care should be taken to avoid contact of the medication with the dog's eyes. Contact of the bare hand with the medication should also be avoided.

Synotic (fluocinolone acetonide and dimethyl sulfoxide) Otic Solution Veterinary is recommended for topical application to the ear canal of the dog only. Do not administer by any other route.

Precautions: Very hygroscopic. Close vial tightly after use. Avoid freezing and excessive heat.

Federal law restricts this drug to use by or on the order of a licensed veterinarian

There should be careful initial evaluation and follow-up of infected ears. Incomplete response or exacerbation of corticosteroid responsive lesions may be due to the presence of an infection which requires identification or antibiotic sensitivity testing, and the use of the appropriate antimicrobial agent. As with any corticosteroid, animals with a generalized infection should not be treated with this product without proper supportive antimicrobial therapy. Preparations with DMSO should not be used in pregnant animals since studies in chick embryos and guinea pigs have indicated it is teratogenic and embryotoxic.

Side Effects: A transient, but mild, stinging sensation may be experienced by some animals when the solution is applied to denuded areas. The effect will disappear as healing progresses. A temporary increase in temperature of the area may also be noted.

Corticosteroid therapy will generally cause a remission of signs of allergic origin. However, until the causative agent is identified and removed from the animal's environment, the condition may recur when therapy is terminated.

Ordinarily, side effects are not encountered with topically applied corticosteroids; but as with all drugs, some animals may exhibit unfavorable local and/or systemic reactions. A local reaction may be due to sensitization to the corticosteroid or one of the other components of the solution.

DMSO enhances the percutaneous absorption of topically applied corticosteroids and the veterinarian should be aware of possible systemic reactions in this situation. Accordingly, this product is contraindicated wherever systemic corticosteroids would be dangerous. Adrenal suppression, weight loss and increased susceptibility to infections may be evidenced with the use of this drug, especially in overdosage. Therefore, care should be taken to assure that the recommended dosage is not exceeded.

In the presence of local and/or systemic side effects, the drug should be withdrawn. When a local reaction occurs other therapeutic measures should be instituted. Therapy can usually be resumed at a lower dose once systemic signs abate, without further recurrence of the problem.

Absorption of DMSO following topical application may result in an odorous breath described as oyster or garlic-like with an unpleasant taste. Some animals and clients may find this objectionable but these effects are transient and not considered to be of serious consequence.

How Supplied: Synotic (fluocinolone acetonide and dimethyl sulfoxide) Otic Solution Veterinary available in dropper vials of 8 mL

Fort Dodge Laboratories

Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.


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69142 Highway 59, Suite E, Mandeville, Louisiana 70471
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