Antibiotic Ophthalmic Ointment with Polymyxin B Sulfate
Terramycin (oxytetracycline HCl) is
an antibiotic, bright yellow in color, possessing potent antimicrobial
activity. It is one of the most versatile of the broad-spectrum antibiotics,
and is effective in the treatment of infections due to gram-positive and
gram-negative bacteria, both aerobic and anaerobic, spirochetes, rickettsiae,
and certain of the larger viruses.
Polymyxin B sulfate is one of a group of related antibiotics
derived from Bacillus polymyxa. The polymyxins are
rapidly bactericidal, this action being exclusively against gram-negative
The broad-spectrum effectiveness of Terramycin against both
gram-positive and gram-negative organisms is enhanced by the particular
effectiveness of polymyxin B against infections associated with
gram-negative organisms, especially those due to
Pseudomonas aeruginosa, where polymyxin B is the antibiotic of choice.
In addition, there is evidence to indicate that polymyxin B sulfate
possesses some antifungal activity. The combined antibacterial effect of
Terramycin plus polymyxin is at least additive and, in many instances, an
actual synergistic action is obtained.
Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is a
suspension of oxytetracycline hydrochloride and polymyxin B sulfate in a
special petrolatum base. Each gram of ointment contains oxytetracycline HCl
equivalent to 5 mg of oxytetracycline and 10,000 units of polymyxin B as the
INDICATIONS: Terramycin Ophthalmic
Ointment with Polymyxin B Sulfate is indicated for the prophylaxis and local
treatment of superficial ocular infections due to oxytetracycline- and
polymyxin-sensitive organisms, including infections due to streptococci,
rickettsiae, E. coli, and A.
aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer,
blepharitis in dogs, cats, cattle, sheep, and horses; ocular infections due
to secondary bacterial complications of distemper in dogs, and bacterial
inflammatory conditions which may occur secondary to other infectious
diseases in the above species.
ADMINISTRATION: Terramycin Ophthalmic
Ointment with Polymyxin B Sulfate should be administered topically to the
eye 2-4 times daily.
PRECAUTIONS: Allergic reactions may
occasionally occur. Treatment should be discontinued if reactions are
Note: The use of oxytetracycline and
other antibiotics may result in an overgrowth of resistant organisms such as
Monilia, staphylococci, and other species of bacteria. If new infections due
to non-sensitive bacteria or fungi appear during therapy, appropriate
measures should be taken.
For Animal Use Only