Vetprofen should not be used in dogs exhibiting previous
hypersensitivity to carprofen.
Keep out of reach of children. Not for human use. Consult a physician in
cases of accidental ingestion by humans. For use in dogs only. Do
not use in cats.
All dogs should
undergo a thorough history and physical examination before initiation of
NSAID therapy. Appropriate laboratory tests to establish hematological
and serum biochemical baseline data prior to, and periodically during,
administration of any NSAID should be considered. Owners should be
advised to observe for signs of potential drug toxicity (see Information
for Dog Owners, Adverse Reactions, Animal Safety and Post-Approval
Store at controlled room temperature 15C - 30C (59F - 86F).
As a class, cyclooxygenase inhibitory NSAIDs may be associated with
gastrointestinal, renal and hepatic toxicity. Effects may result from
decreased prostaglandin production and inhibition of the enzyme
cyclooxygenase which is responsible for the formation of prostaglandins
from arachidonic acid.11-14 When NSAIDs inhibit
prostaglandins that cause inflammation they may also inhibit those
prostaglandins which maintain normal homeostatic function. These
anti-prostaglandin effects may result in clinically significant disease
in patients with underlying or pre-existing disease more often than in
healthy patients.12,14 NSAID therapy could unmask occult
disease which has previously been undiagnosed due to the absence of
apparent clinical signs. Patients with underlying renal disease for
example, may experience exacerbation or decompensation of their renal
disease while on NSAID therapy.11-14
The use of parenteral fluids during surgery should be considered to
reduce the potential risk of renal complications when using NSAIDs
Carprofen is an
NSAID, and as with others in that class, adverse reactions may occur
with its use. The most frequently reported effects have been
gastrointestinal signs. Events involving suspected renal, hematologic,
neurologic, dermatologic, and hepatic effects have also been reported.
Patients at greatest risk for renal toxicity are those that are
dehydrated, on concomitant diuretic therapy, or those with renal,
cardiovascular, and/or hepatic dysfunction. Concurrent administration of
potentially nephrotoxic drugs should be approached cautiously, with
appropriate monitoring. Since many NSAIDs possess the potential to
induce gastrointestinal ulceration, concomitant use of carprofen with
other anti-inflammatory drugs, such as corticosteroids and NSAIDs,
should be avoided or very closely monitored. Sensitivity to
drug-associated adverse reactions varies with the individual patient.
For example, carprofen treatment was not associated with renal toxicity
or gastrointestinal ulceration in well-controlled safety studies of up
to ten times the dose in dogs.
Carprofen is not
recommended for use in dogs with bleeding disorders (e.g., Von
Willebrand's disease), as safety has not been established in dogs with
these disorders. The safe use of carprofen in animals less than 6 weeks
of age, pregnant dogs, dogs used for breeding purposes, or in lactating
bitches has not been established. Studies to determine the activity of
carprofen when administered concomitantly with other protein-bound or
similarly metabolized drugs have not been conducted. Drug compatibility
should be monitored closely in patients requiring additional therapy.
Such drugs commonly used include cardiac, anticonvulsant and behavioral
medications. It has been suggested that treatment with carprofen may
reduce the level of inhalant anesthetics needed.15
If additional pain
medication is warranted after administration of the total daily dose of
carprofen, alternative analgesia should be considered. The use of
another NSAID is not recommended. Consider appropriate washout times
when switching from one NSAID to another or when switching from
corticosteroid use to NSAID use.
For use in dogs only. The
recommended dosage for oral administration to dogs is 2 mg/lb (4.4
mg/kg) of body weight daily. The total daily dose may be administered as
2 mg/lb of body weight once daily or divided and administered as 1 mg/lb
(2.2 mg/kg) twice daily. For the control of postoperative pain,
administer approximately 2 hours before the procedure. Caplets are
scored and dosage should be calculated in half-caplet increments.
reactions may include decreased appetite, vomiting, diarrhea, dark or
tarry stools, increased water consumption, increased urination, pale
gums due to anemia, yellowing of gums, skin or white of the eye due to
jaundice, lethargy, incoordination, seizure, or behavioral changes. The vast majority of patients with drug related adverse
reactions recover when the signs are recognized, the drug is
withdrawn, and veterinary care, if appropriate, is initiated.
Federal law restricts this drug to use by or on the order of a licensed