Description:
Schering-Plough
(FLUNIXIN
MEGLUMINE)
Paste - 1500 mg
flunixin/syringe
Veterinary
For Oral Use in
Horses Only
CAUTION
Federal law restricts this drug to
use by or on the order of a licensed veterinarian.
DESCRIPTION
Each 30-gram syringe of
BANAMINE Paste contains flunixin meglumine equivalent to 1500 mg flunixin.
INDICATIONS
BANAMINE Paste is
recommended for the alleviation of inflammation and pain associated with
musculoskeletal disorders in the horse.
ACTIVITY
Flunixin meglumine is a potent nonnarcotic, nonsteroidal, analgesic agent
with anti-inflammatory and antipyretic activity. It is significantly more
potent than pentazocine, meperidine, and codeine as an analgesic in the rat
yeast paw test. Oral studies in the horse show onset of flunixin activity
occurs within 2 hours of administration. Peak response occurs between 12 and
16 hours and duration of activity is 24 to 36 hours.
CONTRAINDICATIONS There are
no known contraindications to this drug when used as directed.
WARNING
Not for use in horses intended for
food.
PRECAUTIONS
The effect of BANAMINE Paste
on pregnancy has not been determined. Studies to date show there is no
detrimental effect on stallion spermatogenesis with or following the
recommended dose of BANAMINE Paste.
SIDE EFFECTS
During field studies with
BANAMINE Paste, no significant side effects were reported.
DOSAGE AND
ADMINISTRATION The
recommended dose of flunixin is 0.5 mg per lb of body weight once daily. The
BANAMINE Paste syringe, calibrated in twelve 250-lb weight increments,
delivers 125 mg of flunixin for each 250 lbs (see dosage table). One syringe
will treat a 1000-lb horse once daily for 3 days, or three 1000-lb horses
one time.
|
DOSAGE TABLE |
|
Syringe Mark* |
Horse Weight (lbs) |
BANAMINE Paste Delivered (g) |
Mg Flunixin Delivered |
|
0 |
- |
- |
- |
|
250 |
250 |
2.5 |
125 |
|
500 |
500 |
5.0 |
250 |
|
750 |
750 |
7.5 |
375 |
|
1000 |
1000 |
10.0 |
500 |
|
*Use dial edge nearest syringe
barrel to mark dose. |
The paste is
orally administered by inserting the nozzle of the syringe through the
interdental space, and depositing the required amount of paste on the back
of the tongue by depressing the plunger.
Treatment may be
given initially by intravenous or intramuscular injection of BANAMINE
Solution, followed by BANAMINE Granules or BANAMINE Paste on days 2 to 5.
BANAMINE treatment should not exceed 5 consecutive days.
TOXICITY
No toxic effects were observed in
rats given oral flunixin 2 mg/kg per day for 42 days. Higher doses produced
ulceration of the gastrointestinal tract. The emetic dose in dogs is between
150 and 250 mg/kg. Flunixin was well tolerated in monkeys dosed daily with 4
mg/kg for 56 days. No adverse effects occurred in horses dosed orally with
1.0 or 1.5 mg/lb for 5 consecutive days.
HOW SUPPLIED
BANAMINE Paste, 1500 mg is
available in a single 30-g syringe.
|