Description:
Fort Dodge
AMINOPENTAMIDE
HYDROGEN SULFATE
Veterinary
Injection and Tablets
DESCRIPTION
CENTRINE (aminopentamide
hydrogen sulfate) is a potent antispasmodic agent. As a cholinergic blocking
agent for smooth muscle, its action is similar to atropine.
ACTION
CENTRINE
effectively reduces the tone and amplitude of colonic contractions to a
greater degree and for a more extended period than does atropine.
CENTRINE effects a
reduction in gastric secretion, a decrease in gastric acidity and a marked
decrease in gastric motility.
The mydriatic and
salivary effects of CENTRINE are less than those produced by atropine at
similar dosage, permitting the control of vomiting and diarrhea with less
distress to the animal due to dryness of the mouth and blurred vision.
INDICATIONS
CENTRINE is
indicated in the treatment of acute abdominal visceral spasm, pylorospasm or
hypertrophic gastritis and associated nausea, vomiting and/or diarrhea.
CONTRAINDICATIONS
CENTRINE should
not be used in animals with glaucoma because of the occurrence of mydriasis.
WARNING
FOR USE IN DOGS
AND CATS ONLY.
PRECAUTIONS
Dryness of the
mouth is the most commonly reported side effect. Blurring of vision may
occur and dryness of the eyes may occur if larger (greater than therapeutic)
doses are used. CENTRINE should be used cautiously, if at all, in pyloric
obstruction because of its action in delaying gastric emptying. These
effects frequently decrease with continued administration of the drug.
Disturbances in urination are relatively infrequent. They vary from slightly
hesitancy in initiating urination to complete inability to urinate; the
latter is an indication for discontinuing the drug. After a day or two, it
may be resumed at a lower dosage level.
DOSAGE
CENTRINE (aminopentamide
hydrogen sulfate) may be administered by subcutaneous or intramuscular
injection or by oral tablets according to the following schedule. If the
desired effect is not obtained, the dosage may be gradually increased up to
a maximum of 5 times the doses listed. When the condition has been brought
under control by parenteral medication, treatment can be continued, if
desired, with 0.2 mg scored tablets according to the dosage schedule.
|
Weight of Animal |
Amount to be Administered
Every 8 to 12 hours |
|
Dosage |
Injectable Volume |
Oral Tablets |
|
10 lbs or
less |
0.1 mg |
0.2 mL |
1/2 Tab |
|
11 lbs to
20 lbs |
0.2 mg |
0.4 mL |
1 Tab |
|
21 lbs to
50 lbs |
0.3 mg |
0.6 mL |
1 1/2 Tabs |
|
51 lbs to
100 lbs |
0.4 mg |
0.8 mL |
2 Tabs |
|
Over 100
lbs |
0.5 mg |
1.0 mL |
2 1/2 Tabs |
CAUTION
Federal law
restricts this drug to use by or on the order of a licensed veterinarian.
HOW SUPPLIED
0.5 mg/mL CENTRINE
(aminopentamide hydrogen sulfate) VETERINARY INJECTION, 10 mL vials.
0.2 mg CENTRINE (aminopentamide
hydrogen sulfate) VETERINARY TABLETS, bottles of 100.
Store at
controlled room temperature 15° to 30°C (59° to 86°F).
|