Description:
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CESTEX®
CESTEX
DESCRIPTION:
Cestex tablets are film-coated and contain 12.5 mg, 25
mg, 50 mg or 100 mg of epsiprantel per tablet.
Epsiprantel is an
anthelmintic that is active as a single dose against the common tapeworms of
cats and dogs. Epsiprantel has a molecular weight of 326 and is chemically
2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benza-zepine.
It is a stable white solid which is sparingly soluble in water. Its chemical
structure is presented below.
ACTION:
Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed
following oral administration, epsiprantel remains at the site of action within
the gastrointestinal tract. Due to digestive process, tapeworm fragments or
proglottids may not be readily visible in the stool.
INDICATIONS:
Cestex tablets are indicated for the removal of the
following:
Feline cestodes:
Dipylidium caninum and Taenia taeniaeformis
Canine cestodes:
Dipylidium caninum and Taenia pisiformis
DOSAGE AND
ADMINISTRATION: Cestex tablets should be administered
orally.
The recommended
dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of
body weight. The following table may be used as a guide:
Dosage
Schedule
Feline
|
Body
Weight |
Dose |
|
Seven
weeks old |
|
up to 10
lb |
12.5 mg |
|
11-20 lb |
25.0 mg |
Canine
|
Body
Weight |
Dose |
|
Seven
weeks old |
|
up to 5
lb |
12.5 mg |
|
6-10 lb |
25.0 mg |
|
11-20 lb |
50.0 mg |
|
21-40 lb |
100.0 mg |
|
41-50 lb |
125.0 mg |
|
51-60 lb |
150.0 mg |
|
61-80 lb |
200.0 mg |
|
81-90 lb |
225.0 mg |
|
91-100 lb |
250.0 mg |
|
101+ lb |
2.5 mg/lb, rounding up to next
whole tablet combination |
Fasting is not
necessary or recommended.
Unless exposure
to the infected intermediate hosts is controlled, reinfection is likely and
retreatment may be required. In the case of D. caninum, an effective flea
control program should be instituted.
SAFETY:
Epsiprantel has been evaluated in cats at 5 times the recommended dose given
once daily for 3 days with no adverse effects noted. In tolerance studies,
epsiprantel produced minimal clinical signs in cats given 40 times the
recommended dose once daily for 4 days.
Epsiprantel has
been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times
recommended dosage) with no significant adverse results. No side effects were
observed during the clinical field studies.
Epsiprantel is
not a cholinesterase inhibitor. During the course of clinical field studies,
Cestex was administered concurrently with diethylcarbamazine citrate (dogs
only), anti-inflammatory agents, insecticides, and nematocides with no drug
incompatibilities noted.
CONTRAINDICATIONS: There are no known contraindications
to the use of this drug.
WARNINGS:
For use in cats and dogs only. Safety of use in pregnant
or breeding animals has not been determined. Keep out of reach of children. Not
for use in humans.
PRECAUTION:
Do not use in kittens or puppies less than 7 weeks of
age.
STORAGE:
Store at controlled room temperature 15°-30°C (59°-86°F).
HOW SUPPLIED:
Cestex tablets are film-coated and contain 12.5 mg, 25
mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described
below:
|
Concentration
|
Weight (lbs) |
Number Tablets/Bottle |
|
Cat |
Dog |
|
12.5 mg |
10 |
5 |
50, 100 |
|
25.0 mg |
20 |
10 |
50, 100 |
|
50.0 mg |
- - |
20 |
25, 50 |
|
100.0 mg
|
- - |
40 |
25, 50 |
CAUTION:
Federal law restricts this drug to use by or on the order of a licensed
veterinarian.
Cestex (epsiprantel)
tablets are indicated for the removal of tapeworms in the cat (Dipylidium
caninum and Taenia taeniaeformis) and dog (Dipylidium caninum
and Taenia pisiformis).
|