Description:
For Oral Use In
Horses Only
Description:
Equiphen Paste
(Phenylbutazone) is a synthetic,
non-hormonal, anti-inflammatory,
antipyretic compound useful in the
management of inflammatory
conditions. The apparent analgesic
effect is probably related mainly to the
anti-inflammatory properties of the
compound.
Chemically,
phenylbutazone is 4-butyl-1, 2-diphenyl-3,
5-pyrazolidine-dione. It is a
pyrazolone derivative, entirely unrelated
to the steroid hormones.
Indications
For the relief of inflammatory conditions associated with the
musculoskeletal system in horses.
Contraindications:
Use with
caution in patients who have a history of
drug allergy.
Precautions:
Stop
medicine at the first sign of
gastrointestinal upset, jaundice, or blood
dyscrasia. Authenticated cases of
agranulocytosis associated with the drug
have occurred in man; fatal reactions,
although rare, have been reported in dogs
after long-term therapy. To guard
against this possibility, conduct routine
blood counts at weekly intervals during
the early phase of therapy and at
intervals of two weeks thereafter.
Any significant fall in the total white
count, relative decrease in granulocytes,
or black or tarry stools, should be
regarded as a signal of appropriate
counter measures. In the treatment
of inflammatory conditions associated with
infections, specific anti-infective
therapy is required.
Dosage and Administration:
Each increment on the plunger delivers 1 gram of
phenylbutazone. Oral dose of 1 to 2 grams of phenylbutazone per 500 lbs.
of body weight, but not to exceed 4 grams daily. Use a relatively high
dose for the first 48 hours, then reduce gradually to a maintenance dose.
Maintain lowest dose capable of producing desired clinical response.
Guidelines to Successful Therapy:
1) Use a relatively high dose for the first
48 hours, then reduce gradually to a maintenance dose. Maintain lowest
dose capable of producing desired clinical response.
2) Response to EQUIPHEN PASTE
(PHENYLBUTAZONE) therapy is prompt, usually occurring within 24 hours. If
no significant clinical response is evident after 5 days, re-evaluate diagnosis
and therapeutic approach.
3) When administering EQUIPHEN PASTE
(PHENYLBUTAZONE) the oral cavity should be empty. Deposit paste on back of
tongue by depressing plunger that has been previously set to deliver the correct
dose.
4) Many chronic conditons will respond to
EQUIPHEN PASTE (PHENYLBUTAZONE) therapy, but discontinuance of treatment may
result in recurrence of symptoms.
Warning:
Not for use in horses intended for food.
Storage:
Store at controlled room temperature (59-86 F)
Offered in an apple flavored formulation with each 60 cc
syringe containing 12 grams of phenylbutazone.
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