Marin For Large Dogs

Nutramax Marin provides support for the liver with silybin, the most active component of milk thistle in a more bioavailable form, and vitamin E. Silybin is the most biologically active component of an extract known as silymarin. Silymarin/silypin has been shown to have beneficial effects on liver function. Vitamin E, a membrane-associated antioxidant, helps protect the liver against oxidant injury.

Silybin/silymarin has many different mechanisms of action. In-vitro and in-vivo studies have shown that it protects agains oxidative stress; promotes protein synthesis within hepatocytes, a mechanism for liver cell regeneration; inhibits leukotriene production, which can be beneficial as production of leukotrienes is a component of the inflammatory response; stimulates biliary flow and production of hepatoprotective bile salts (e.g. beta-muricholate and ursodexycholate) and increases levels of glutathione.

Vitamin E, a emberate-associated antioxidant, benefits liver function because oxidant damanage to hepatocytes can affect liver health. Vitamin E has been shown to reduce the oxidative damage to the hepatocyte mitochondrial membranes caused by hydrophobic bile salts (these bile salts build up in the liver when bile flow is impaired) Vitamin E use has been reported in dogs for its antioxidant role that also help to support hepatic health.

Marin, Denosyl and Denamarin support the liver through differing actions and may be used individually or in combination depending on your pet's needs. Your veterinarian can advise you on the best way to support your dog's liver.