Penicillin G Benzathine and Penicillin G Procaine Aqueous Suspension
Veterinary Injection for Use in Beef Cattle
Antibiotic
FOR SUBCUTANEOUS USE ONLY
Penicillin G Benzathine and Penicillin G
Procaine is indicated for treatment of the following bacterial infections in beef
cattle due to penicillin-susceptible micro-organisms that are susceptible to
the serum levels common to this particular dosage form, such as:
1.Bacterial Pneumonia (shipping fever complex)
(Streptococcus spp.,
Actinomyces pyogenes, Staphylococcus aureus)
2.Upper Respiratory Infections such as Rhinitis or
Pharyngitis (Actinomyces pyogenes)
3.Blackleg (Clostridium chauvoei)
DESCRIPTION: Each mL contains 150,000
units penicillin G benzathine; 150,000 units penicillin G procaine and,
approximately: 0.08% sodium carboxymethylcellulose; 0.40% sodium citrate
dihydrate; 1.17% lecithin; 0.31% povidone; 0.04% polysorbate 40; 0.06%
sorbitan monopalmitate 40; 0.01% propylparaben, 0.12% methylparaben, and
0.25% phenol as preservatives; trisodium phosphate, as required to adjust
pH; water for injection q.s.
ACTION: Penicillin G is an antibiotic
which shows a marked bactericidal effect against certain organisms during
their growth phase. It is relatively specific in its action against
Gram-positive bacteria but is usually ineffective against Gram-negative
organisms.
It is normally recommended that any bacterial infection be
treated as early as possible and with a dosage which will give effective
blood levels. Although the recommended dosage of Penicillin
G Benzathine and Penicillin G Procaine
will give longer detectable penicillin blood levels than penicillin G
procaine alone, it is recommended that a second dose be administered at 48
hours when treating a penicillin-susceptible bacterial infection.
The use of antibiotics in the management of disease is based
on an accurate diagnosis and an adequate course of treatment. When properly
used in the treatment of diseases caused by penicillin-susceptible
organisms, most animals treated with Penicillin G Benzathine
and Penicillin G Procaine
show a noticeable improvement within 24 to 48 hours. If improvement does not
occur within this period of time, the diagnosis and course of treatment
should be reevaluated. It is recommended that the diagnosis and treatment of
animal diseases be carried out by a veterinarian. Since many diseases look
alike but require different types of treatment, the use of professional
veterinary and laboratory services can reduce treatment time, costs, and
needless losses. Good housing, sanitation, and nutrition are important in
the maintenance of healthy animals and are essential in the treatment of
disease.
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Residue Warnings:
Beef cattle should be withheld from
slaughter for food use for 30 days following last treatment.
Treatment in beef cattle must be limited to two (2) doses, BY
SUBCUTANEOUS INJECTION ONLY. Do not inject intramuscularly. A
withdrawal period has not been established for this product in
preruminating calves. Do not use in calves to be processed for veal. |
PRECAUTIONS: Exceeding the recommended
doses and dosage levels may result in antibiotic residues beyond the
withdrawal time. Do not inject this material intramuscularly.
Penicillin G is a substance of low toxicity. However, side
effects, or so-called allergic or anaphylactic reactions - sometimes fatal,
have been known to occur in animals hypersensitive to penicillin and
procaine. Such reactions can occur unpredictably with varying intensity.
Animals administered penicillin G should be kept under close observation for
at least one-half hour. Should allergic or anaphylactic reactions occur,
discontinue use of the product and immediately administer epinephrine
following manufacturer’s recommendations; call a veterinarian.
As with all antibiotic preparations, use of this drug may
result in overgrowth of nonsusceptible organisms, including fungi. A lack of
response by the treated animal, or the development of new signs or symptoms
suggest that an overgrowth of nonsusceptible organisms has occurred. In such
instances, consult your veterinarian.
Since bactericidal drugs may interfere with the
bacteriostatic action of tetracyclines, it is advisable to avoid giving
penicillin in conjunction with tetracyclines.
Penicillin G Benzathine and Penicillin G
Procaine
should be stored under refrigeration 2°-8°C (36°-46°F). Avoid freezing. Warm
to room temperature, and shake well before using.
ADMINISTRATION: The recommended dosage
for beef cattle should be administered by SUBCUTANEOUS INJECTION ONLY.
Failure to use the subcutaneous route of administration may result in
antibiotic residues in meat beyond the withdrawal time.
DOSAGE: Beef Cattle: 2 mL per 150 lb
body weight GIVEN SUBCUTANEOUSLY ONLY (2,000 units penicillin G procaine and
2,000 units penicillin G benzathine per lb body weight). Treatment should be
repeated in 48 hours.
IMPORTANT: Treatment in beef cattle
should be limited to two (2) doses given by subcutaneous injection only.
DIRECTIONS FOR USE: A thoroughly
cleaned, sterile needle and syringe should be used for each injection
(needles and syringes may be sterilized by boiling in water for 15 minutes).
Before withdrawing the solution from the bottle, disinfect the rubber cap on
the bottle with a suitable disinfectant, such as 70 percent alcohol. The
injection site should be similarly cleaned with the disinfectant. Needles of
14 to 16 gauge and not more than 1 inch long are adequate for injections.
A subcutaneous injection should be made by pinching up a
fold of the skin between the thumb and forefinger. The mid-neck region is
the preferred injection site. Insert the needle under the fold in a
direction approximately parallel to the surface of the body. When the needle
is inserted in this manner the medication will be delivered underneath the
skin between the skin and the muscles. Proper restraint, such as the use of
a chute and nose lead, is needed for proper administration of the product.
SHAKE WELL BEFORE USING
FOR ANIMAL USE ONLY
RESTRICTED DRUG(S) (CALIFORNIA)
NOT FOR HUMAN USE
USE ONLY AS DIRECTED
PACKAGE INFORMATION: Penicillin G Benzathine
and Penicillin G Procaine
is available in vials of 100 mL and 250 mL with each mL containing 150,000
units penicillin G benzathine and 150,000 units penicillin G procaine.
Store under refrigeration 2°-8°C (36°-46°F)
Avoid Freezing