(Phenylpropanolamine
Hydrochloride)
25 mg Chewable Tablets
Each Phenylpropanolamine (PPA) chewable tablet
contains 25 mg of phenylpropanolamine hydrochloride. Phenylpropanolamine is
an α- and β-adrenergic agonist that stimulates smooth muscle contraction of
the internal urethral sphincter, increasing urethral sphincter tone and
closure of the bladder neck. Reduced urethral sphincter tone may result in
urinary incontinence, a condition seen in primarily in ovariohysterectomized
bitches but also in aged, obese bitches and occasionally in neutered male or
intact dogs.
Indications:
PPA is indicated for the control of urinary
incontinence caused by urethral sphincter incompetence in female dogs.
Dosage & Administration:
3 mg/kg body weight per day PO, administered as 1.5
mg/kg PO BID or 1.0 mg/kg PO TID.
Patients may achieve an adequate clinical response
with a lower dose. Dosage may be rounded to the nearest 6.25 mg (1/4 tablet)
for practical dosing. Please refer to the following dosage charts:
|
Body Weight (lb)
|
25 mg tablet dose BID
|
|
<7
|
Not recommended*
|
|
8-15
|
0.25
|
|
16-23
|
0.5
|
|
24-31
|
0.75
|
|
32-39
|
1
|
|
40-48
|
1.25
|
|
49-57
|
1.5
|
|
58-67
|
1.75
|
|
68-77
|
2
|
|
78-94
|
Use 50 mg tablet
|
|
95-113
|
Use 50 mg tablet
|
|
114-137
|
Use 50 mg tablet
|
|
138-151
|
Use 50 mg tablet
|
|
Body Weight (lb)
|
25 mg tablet dose TID
|
|
< 7
|
Not recommended*
|
|
8-15
|
0.25
|
|
16-30
|
0.5
|
|
31-43
|
0.75
|
|
44-57
|
1
|
|
58-72
|
1.25
|
|
73-86
|
1.5
|
|
87-101
|
1.75
|
|
102-115
|
2
|
|
116-144
|
Use 50 mg tablet
|
|
145-151
|
Use 50 mg tablet
|
* Veterinarian may compound the drug for patients
weighing 7 lb and under
In order for this medication to be effective, it
must be administered as directed by the veterinarian; missed doses will
negate its effect. It may take several days for the full benefit of the drug
to take place.
Warnings:
Not for human use. Keep this and all medications out
of the reach of children. PPA should be avoided or used with caution in dogs
with glaucoma, cardiovascular disease, hypertension, renal insufficiency,
and diabetes mellitus.
Precautions:
Possible side effects include restlessness, CNS
excitation, irritability, tachycardia, hypertension, and anorexia. PPA
should not be administered with other sympathomimetic drugs, tricyclic
antidepressants, or within two weeks of administering monoamine oxidase
inhibitors, due to the risk of acute hypertension. Risk of cardiac
arrhythmia is increased when PPA is administered concomitantly with
halogenated gas anesthetic agents.
Adverse Reactions:
Adverse reactions related to administration of PPA
may include restlessness, excitation, irritability, tachycardia,
hypertension, vomiting, and anorexia.
FOR USE IN DOGS ONLY
Caution:
Federal law restricts this drug to use by or on the
order of a licensed veterinarian.
Storage:
Store at 2°-30°C (36°-86°F). Keep container tightly
closed.
How Supplied:
PPA 25 mg tablets are available in 60 count and 180
count bottles.
Keep out of reach of children.
For use in animals only.