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Penicillin G Benzathine & Procaine
Penicillin G Benzathine and Penicillin G Procaine is
indicated for treatment of the following bacterial infections in beef cattle
due to penicillin-susceptible micro-organisms that are susceptible to the serum
levels common to this particular dosage form, such as:
Bacterial Pneumonia (shipping fever complex) (Streptococcus
spp., Actinomyces pyogenes, Staphylococcus aureus)
Upper Respiratory Infections such as Rhinitis or Pharyngitis
(Actinomyces pyogenes)
Blackleg (Clostridium chauvoei)
FOR SUBCUTANEOUS USE ONLY
- Veterinary Injection for Use in Beef Cattle
- "Long-Acting Penicillin"
- Off-Label Use in Companion Animals
Action: Penicillin G is an antibiotic which shows a marked
bactericidal effect against certain organisms during their growth phase. It is
relatively specific in its action against Gram-positive bacteria but is usually
ineffective against Gram-negative organisms.
It is normally recommended that any bacterial infection be
treated as early as possible and with a dosage which will give effective blood
levels. Although the recommended dosage of Penicillin G Benzathine and
Penicillin G Procaine will give longer detectable penicillin blood levels than
penicillin G procaine alone, it is recommended that a second dose be
administered at 48 hours when treating a penicillin-susceptible bacterial
infection.
The use of antibiotics in the management of disease is based
on an accurate diagnosis and an adequate course of treatment. When properly
used in the treatment of diseases caused by penicillin-susceptible organisms,
most animals treated with Penicillin G Benzathine and Penicillin G Procaine
show a noticeable improvement within 24 to 48 hours. If improvement does not
occur within this period of time, the diagnosis and course of treatment should
be reevaluated. It is recommended that the diagnosis and treatment of animal diseases
be carried out by a veterinarian. Since many diseases look alike but require
different types of treatment, the use of professional veterinary and laboratory
services can reduce treatment time, costs, and needless losses. Good housing,
sanitation, and nutrition are important in the maintenance of healthy animals
and are essential in the treatment of disease.
Residue Warnings: Beef cattle should be withheld from
slaughter for food use for 30 days following last treatment. Treatment in beef
cattle must be limited to two (2) doses, BY SUBCUTANEOUS INJECTION ONLY. Do not
inject intramuscularly. A withdrawal period has not been established for this
product in preruminating calves. Do not use in calves to be processed for veal.
Precautions: Exceeding the recommended doses and dosage
levels may result in antibiotic residues beyond the withdrawal time. Do not
inject this material intramuscularly.
Penicillin G is a substance of low toxicity. However, side
effects, or so-called allergic or anaphylactic reactions - sometimes fatal,
have been known to occur in animals hypersensitive to penicillin and procaine.
Such reactions can occur unpredictably with varying intensity. Animals
administered penicillin G should be kept under close observation for at least
one-half hour. Should allergic or anaphylactic reactions occur, discontinue use
of the product and immediately administer epinephrine following manufacturer's
recommendations; call a veterinarian.
As with all antibiotic preparations, use of this drug may
result in overgrowth of nonsusceptible organisms, including fungi. A lack of
response by the treated animal, or the development of new signs or symptoms
suggest that an overgrowth of nonsusceptible organisms has occurred. In such
instances, consult your veterinarian.
Since bactericidal drugs may interfere with the
bacteriostatic action of tetracyclines, it is advisable to avoid giving
penicillin in conjunction with tetracyclines.
Administration: The recommended dosage for beef cattle
should be administered by SUBCUTANEOUS INJECTION ONLY. Failure to use the
subcutaneous route of administration may result in antibiotic residues in meat
beyond the withdrawal time.
Dosage: Beef Cattle: 2 mL per 150 lb body weight GIVEN
SUBCUTANEOUSLY ONLY (2,000 units penicillin G procaine and 2,000 units
penicillin G benzathine per lb body weight). Treatment should be repeated in 48
hours.
Important: Treatment in beef cattle should be limited to two
(2) doses given by subcutaneous injection only.
Directions For Use: A thoroughly cleaned, sterile needle and
syringe should be used for each injection (needles and syringes may be
sterilized by boiling in water for 15 minutes). Before withdrawing the solution
from the bottle, disinfect the rubber cap on the bottle with a suitable
disinfectant, such as 70 percent alcohol. The injection site should be
similarly cleaned with the disinfectant. Needles of 14 to 16 gauge and not more
than 1 inch long are adequate for injections.
A subcutaneous injection should be made by pinching up a
fold of the skin between the thumb and forefinger. The mid-neck region is the
preferred injection site. Insert the needle under the fold in a direction
approximately parallel to the surface of the body. When the needle is inserted
in this manner the medication will be delivered underneath the skin between the
skin and the muscles. Proper restraint, such as the use of a chute and nose
lead, is needed for proper administration of the product.
SHAKE WELL BEFORE USING
FOR ANIMAL USE ONLY
NOT FOR HUMAN USE
USE ONLY AS DIRECTED
Package Information: Penicillin G Benzathine and Penicillin
G Procaine is available in vials of 100 mL and 250 mL with each mL containing
150,000 units penicillin G benzathine and 150,000 units penicillin G procaine.
Penicillin G Benzathine and Penicillin G Procaine should be
stored under refrigeration 2°-8°C (36°-46°F). Avoid freezing. Warm to room
temperature, and shake well before using.
Avoid Freezing
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