K-BROVET Oral Solution
K-BROVET potassium bromide is used to treat seizure disorders in
dogs. It can be used in addition to therapy with other agents or as the sole
K-BROVET Oral Solution is a butterscotch vanilla flavored
solution containing 250 mg/mL of potassium bromide, cyanocobalamin and
K-BROVET Chewable Tablets are liver flavored tablets containing
250 mg or 500 mg of potassium bromide and cyanocobalamin.
DOSAGE AND ADMINISTRATION
Recommended Dosage for K-BROVET Oral Solution and Tablets:
To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO
daily for 5 days then reduce to 30 mg/kg PO once daily. To achieve a serum
level of approximately 1.5 mg/mL, give 160 mg/kg PO for 5 days and then
reduce to 40 mg/kg PO once daily thereafter.
Among dogs responses to bromide may vary, treatment should be tailored to
the individual dog, based on serum bromide concentration, success of seizure
control, and the observation of adverse effects. Steady state serum
concentrations generally take 4 to 5 months in dogs; therapeutic
concentrations may be reached before steady state at about 4 weeks after the
beginning of treatment, serum bromide concentration may be tested to assess
the response to product and, if results are satisfactory, the next testing
for steady state serum levels is typically about 4 months. If the dog's
serum concentration is within range and the dog is doing well in the
therapeutic range, serum concentration may then be tested every 6 to 12
months. Serum bromide is typically evaluated at the end of the loading
period, then as described above when an animal is started with a loading
Dogs - An oral dose of 30 mg of Bromide per kg of body weight
every twelve hours for 115 days produced a steady state serum concentration
of 2.45 mg/mL (range, 1.78 to 2.69 mg/mL) in Beagles fed a diet containing
This medication should be used cautiously in older animals as they will
be more susceptible to adverse effects. This medication is not indicated for
use in cats.
Possible Side Effects:
Dog may experience drowsiness when taking K-BROVET, but this will generally go away after approximately 3 weeks. Increased hunger, thirst,
urination, vomiting, constipation, anorexia, and uncoordinated movements may
occur with K-BROVET. During the load in dose increased nausea may be
There is no information on the relative frequency of pancreatitis in dogs
associated with bromide therapy alone. However, pancreatitis has been
reported to be more frequent in dogs on concurrent phenobarbital and bromide
therapy than dogs on phenobarbital alone.
Personality changes have been occasionally reported in dogs on bromide,
including attention seeking, irritability or aggression, and aimless pacing.
Drug interactions and/or related effects
Medications and foods containing chloride, bromide and chloride compete
for reabsorption by the kidneys; increased amounts of chloride can promote
loss of bromide in the urine, leading to a lowering of serum bromide
concentrations: Decreased chloride consumption will promote increased renal
reabsorption of bromide.
Halothane anesthesia (when inhaled a percentage of halothane is
metabolized by dogs to produce bromide, along with other compounds; peak
serum concentration occurs within about a day and, in one group of dogs,
ranged from 0.04 to 0.088 mg/mL and persisted, with some diminishment, for
at least ten days. Consideration should be given to
animals that must have repeated anesthesia or that already require high
serum bromide concentration for seizure control. Increased bromide levels
due to metabolism of halothane are unlikely to be a significant risk for
bromide toxicity in most dogs.
K-BROVET should not be used in animals with a history of
hypersensitivity to Bromide or any of the components of the solution or
Oral Solution 2 oz (59 ml) with convenient dropper and 10 oz (300 ml)
500mg Tablet (60ct) bottle
250mg Tablet (60ct) bottle
Keep out of reach of children and animals
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Store in a tightly sealed container at room temperature (59-86°F).
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.