Levocrine Canine Thyroid Chewable Tablets
Dechra Levocrine Chewable Tablets provides thyroid
replacement therapy for all conditions of inadequate production of thyroid
hormones in dogs.
Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate
metabolism, growth, development and differentiation of tissues. It increases the
rate of energy exchange and increases the maturation rate of the epiphyses.
Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after
oral administration. Following absorption, the compound becomes bound to the
serum alpha globulin fraction.
Levocrine Chewable Tablets make it easier to administer the daily dose to
dogs. Administer tablets free choice to the dog or crumble over the dog's food.
- Effective therapy with consistent clinical results
- An affordable alternative to conventional tablets for managing canine
- Very palatable, small chewable, scored tablets
- Hydrolyzed soy based flavoring for dogs with food sensitivities or
intolerances - Safe for Food Allergy Dogs
- Color-coded bottle labels in nine strengths for convenient dispensing
and dosing flexibility
Hypothyroidism is the generalized metabolic disease resulting from deficiency
of the thyroid hormones levothyroxine (T
4) and liothyronine (T3).
Each tablet, Pala-Tech Canine Thyroid Chewable Tablets (Levothyroxine Sodium,
USP), will provide levothyroxine (T
4) as a substrate for the
physiologic deiodination to liothyronine (T
3). Administration of
levothyroxine sodium alone will result in complete physiologic thyroid
Canine hypothyroidism is usually primary, i.e. due to the atrophy of the
thyroid gland. In the majority of cases the atrophy is associated with
lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of
yet unknown etiology. Less than 10 percent of cases of hypothyroidism are
secondary, i.e. due to deficiency of thyroid stimulating hormone (TSH). TSH
deficiency may occur as a component of congenital hypopituitarism or as an
acquired disorder in adult dogs, in which case it is invariably due to the
growth of a pituitary tumor.
Hypothyroidism usually occurs in middle-aged and older dogs although the
condition will sometimes be seen in younger dogs of the larger breeds. Neutered
animals of either sex are also frequently affected, regardless of age. The
following are clinical signs of hypothyroidism in dogs:
- Lethargy, lack of endurance, increased sleeping
- Reduced interest, alertness and excitability
- Slow Heart rate, weak apex heartbeat and pulse, low voltage on ECG
- Preference for warmth, low body temperature, cool skin
- Increased body weight
- Still and slow movements, dragging of the front feet
- Head tilt, disturbed balance, unilateral facial paralysis
- Atrophy of the epidermis, thickening of the dermis
- Surface and follicular hyperkeratosis, pigmentation (skin
- Puffy face, blepharoptosis, tragic expression
- Dry, coarse, sparse haircoat, slow regrowth after clipping, brittle
- Retarded turnover of hair (carpet coat of boxers)
- Dry, flaky skin
- Excessive shedding; bald spots
- Infections, particularly of the skin and ears
- Excessive grooming
Shortening of absence of estrus, lack of libido
Dry feces; occasional diarrhea
- Clinical Pathological:
- Normochromic, normocytic anemia
- Elevated serum creatinine phosphokinase
Dosage: The usual dose in dogs is 0.1mg/10 pounds of body
weight. Levocrine Chewable Tablets may be administered orally in placed in food.
The dose is maintained by periodic blood tests to determine the T4 level.
Animals with hypothyroidism are usually treated with Levothyroxine for life.
If given at the proper dose as determined by
blood tests there should be no side effects. Overdose will result in the
symptoms of thyrotoxicosis which may include increased thirst, urination and
hunger, hyperactivity, personality change, and reduced heat tolerance.
This medication should not be used in animals allergic to it. Do not use in
animals with untreated adrenal insufficiency (Addison's disease), use with
caution in animals with high blood pressure. Use with caution when given with
warfarin, theophylline, digoxin, phenytoin and barbiturates. Give 1 hour before
or 4 hours after vitamin/mineral combinations containing iron or calcium. Always
tell your veterinarian and pharmacist what other medications your pet is taking.
There can be differences in the action of Levothyroxine when changing brands. As
a result, it may be necessary to retest T4 levels when switching brands.
Levothyroxine is contraindicated in thyrotoxicosis, acute myocardial infarction
and uncorrected adrenal insufficiency. Use in pregnant bitches has not been
In the event of an overdose:
Contact your veterinarian or veterinary emergency room. Symptoms of overdose (thyrotoxicosis)
may include increased thirst, urination and hunger, hyperactivity, personality
change, and reduced heat tolerance.
Keep this medication in the container it came in, tightly closed. Store tablets
at room temperature, away from excess heat, light and moisture. Do not store in
the bathroom. Throw away any medication that is outdated or no longer needed.
Federal law restricts this drug to use by or on the order of a licensed
Keep out of reach of children and pets. Packaged with childproof safety cap
How Supplied: Dosage strengths 0.1 mg to 1.0 mg. Package
sizes 180 and 1000 chewable tablets. Packaged with childproof safety cap on
Dechra Veterinary Products
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.