Urinary tract infections may require treatment for 10-14 days or longer. The maximum duration of treatment should not exceed 30 days.
Clavamox (amoxicillin trihydrate/clavulanate potassium) is an orally
administered formulation comprised of the broad-spectrum antibiotic Amoxi (amoxicillin trihydrate) and clavulanate
potassium (the potassium salt of clavulanic acid).
Amoxicillin trihydrate is a
semisynthetic antibiotic with a broad spectrum of bactericidal activity
against many gram-positive and gram-negative, aerobic and anaerobic
Clavulanic acid, an inhibitor
of ?-lactamase enzymes, is produced by the fermentation of
Streptomyces clavuligerus. Clavulanic acid by
itself has only weak antibacterial activity.
Contraindications: The use of this drug is contraindicated in animals with a history of an allergic reaction to any of the penicillins or cephalosporins.
Adverse Reactions: Clavamox contains a semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.
Warning: Safety of use in pregnant or breeding animals has not been determined. For use in dogs and cats only.
Clavamox is stable in the presence of gastric acid and is not significantly
influenced by gastric or intestinal contents. The 2 components are rapidly
absorbed resulting in amoxicillin and clavulanic acid concentrations in
serum, urine, and tissues similar to those produced when each is
Amoxicillin and clavulanic
acid diffuse readily into most body tissues and fluids with the exception of
brain and spinal fluid, which amoxicillin penetrates adequately when
meninges are inflamed. Most of the amoxicillin is excreted unchanged in the
urine. Clavulanic acid's penetration into spinal fluid is unknown at this
time. Approximately 15% of the administered dose of clavulanic acid is
excreted in the urine within the first 6 hours.
Clavamox combines the
distinctive properties of a broad-spectrum antibiotic and a ?-lactamase
inhibitor to effectively extend the antibacterial spectrum of amoxicillin to
include ?-lactamase as well as non-?-lactamase-producing aerobic and
Amoxicillin is bactericidal in action and acts through the inhibition of
biosynthesis of cell wall mucopeptide of susceptible organisms. The action
of clavulanic acid extends the antimicrobial spectrum of amoxicillin to
include organisms resistant to amoxicillin and other ?-lactam antibiotics.
Amoxicillin/clavulanate has been shown to have a wide range of activity
which includes ?-lactamase-producing strains of both gram-positive and
gram-negative aerobes, facultative anaerobes, and obligate anaerobes.
Aerobic bacteria, including
Staphylococcus aureus*, ?-lactamase-producing
Staphylococcus aureus* (penicillin resistant),
Staphylococcus epidermidis, Staphylococcus intermedius, Streptococcus
faecalis, Streptococcus species*, Corynebacterium
pyogenes, Corynebacterium species,
Erysipelothrix rhusiopathiae, Bordetella bronchiseptica,
Escherichia coli*, Proteus mirabilis, Proteus
species, Enterobacter species,
Klebsiella pneumoniae, Salmonella dublin, Salmonella typhimurium,
Pasteurella multocida*, Pasteurella hemolytica,
Studies have demonstrated that
both aerobic and anaerobic flora are isolated from gingival cultures of dogs
with clinical evidence of periodontal disease. Both gram-positive and
gram-negative aerobic and anaerobic subgingival isolates indicate
sensitivity to amoxicillin/clavulanic acid during antimicrobial
Federal law restricts this drug to use by or on the order of a licensed veterinarian
Clavamox Tablets are supplied 62.5 mg, 125 mg, 250 mg and 375 mg sizes.
Pfizer Animal Health