CONVENIA Injection is the first antibiotic for dogs and cats that ensures a course of treatment in a single injection. One dose of Covenia provides up to 14 days of safe and effective antibiotic treatment for the most common skin infections.
CONVENIA indicated for the treatment of skin
infections (secondary superficial pyoderma, abscesses, and wounds) in dogs
caused by susceptible strains of Staphylococcus intermedius and
Streptococcus canis. CONVENIA is indicated for the treatment of
skin infections (wounds and abscesses) in cats caused by susceptible strains of
CONVENIA is well-tolerated, and its safety has been
demonstrated in juvenile and adult dogs and cats.
Antimicrobial for Subcutaneous Injection in Dogs and Cats Only
Dosage and Administration:
CONVENIA should be administered as a single subcutaneous
injection of 3.6 mg/lb (8 mg/kg) body weight. A second subcutaneous injection of
3.6 mg/lb (8 mg/kg) may be administered if response to therapy is not complete.
The decision for a second injection for any individual dog should take into
consideration such factors as progress toward clinical resolution, the
susceptibility of the causative organisms, and the integrity of the dog's
host-defense mechanisms. Therapeutic drug concentrations after the first
injection are maintained for 7 days for S. intermedius infections and
for 14 days for S. canis (Group G) infections. Maximum treatment should
not exceed 2 injections.
CONVENIA should be administered as a single, one-time
subcutaneous injection at a dose of 3.6 mg/lb (8 mg/kg) body weight. After an
injection of CONVENIA, therapeutic concentrations are maintained for
approximately 7 days for Pasteurella multocida infections.
General Dosing Information
A sample of the lesion should be obtained for culture
and susceptibility testing prior to beginning antimicrobial therapy. Once
results become available, continue with appropriate therapy. If acceptable
response to treatment is not observed, or if no improvement is seen within 3 to
4 days, then the diagnosis should be re-evaluated and appropriate alternative
CONVENIA may persist in the body for up to 65 days. The
effect of remaining concentrations of cefovecin on any subsequent antimicrobial
therapies has not been determined. Fluoroquinolone and aminoglycoside
antimicrobials have been reported to be compatible with cephalosporin
Dose for CONVENIA at 8 mg/kg Body Weight
5 lbs . . . 0,23 ml
10 lbs . . . 0.45 ml
15 lbs . . . 0.67 ml
20 lbs . . . 0.90 ml
40 lbs . . . 1.8 ml
80 lbs . . . 3.6 ml
Preparation of Solution For Injection: To
deliver the appropriate dose, aseptically reconstitute CONVENIA with 10 mL
sterile water for injection. Shake and allow vial to sit until all material is
visually dissolved. The resulting solution contains cefovecin sodium equivalent
to 80 mg/mL cefovecin. CONVENIA is light sensitive. The vial should be stored in
the original carton and refrigerated when not in use. Use the entire contents of
the vial within 56 days of reconstitution.
Contraindications: CONVENIA is contraindicated in
dogs and cats with known allergy to cefovecin or to ?-lactam (penicillins and
cephalosporins) group antimicrobials. Anaphylaxis has been reported with the use
of this product in foreign market experience. If an allergic reaction or
anaphylaxis occurs, CONVENIA should not be administered again and appropriate
therapy should be instituted. Anaphylaxis may require treatment with epinephrine
and other emergency measures, including oxygen, intravenous fluids, intravenous
antihistamine, corticosteroids, and airway management, as clinically indicated.
Adverse reactions may require prolonged treatment due to the prolonged systemic
drug clearance (65 days).
Warnings: Not for use in humans. Keep this and all
drugs out of reach of children. Consult a physician in case of accidental
human exposure. For subcutaneous use in dogs and cats only. Antimicrobial drugs,
including penicillins and cephalosporins, can cause allergic reactions in
sensitized individuals. To minimize the possibility of allergic reactions, those
handling such antimicrobials, including cefovecin, are advised to avoid direct
contact of the product with the skin and mucous membranes.
PRECAUTIONS: Prescribing antibacterial drugs in
the absence of a proven or strongly suspected bacterial infection is unlikely to
provide benefit to treated animals and may increase the risk of the development
of drug-resistant animal pathogens.
The safe use of CONVENIA in dogs or cats less than 4
months of age and in breeding or lactating animals
has not been determined. Safety has not been established for IM or IV
administration. The long-term effects on injection sites have not been
determined. CONVENIA is slowly eliminated from the body, approximately 65 days
is needed to eliminate 97% of the administered dose from the body. Animals
experiencing an adverse reaction may need to be monitored for this duration.
CONVENIA has been shown to result in an increase in free concentrations of carprofen, furosemide,
doxycycline, and ketoconazole. Concurrent use of these or other drugs that have
a high degree of protein-binding (e.g. NSAIDs, propofol, cardiac,
anticonvulsant, and behavioral medications) may compete with cefovecin-binding
and cause adverse reactions.
Positive direct Coombs' test results and false positive
reactions for glucose in the urine have been reported during treatment with some
cephalosporin antimicrobials. Cephalosporin antimicrobials may also cause
falsely elevated urine protein determinations. Some antimicrobials, including
cephalosporins, can cause lowered albumin values due to interference with
certain testing methods.
Occasionally, cephalosporins and NSAIDs have been
associated with myelotoxicity, thereby creating a toxic neutropenia.
Other hematological reactions seen with cephalosporins include neutropenia,
anemia, hypoprothrombinemia, thrombocytopenia, prolonged prothrombin time (PT)
and partial thromboplastin time (PTT), platelet dysfunction and transient
increases in serum aminotransferases.
Dogs: Lethargy, anorexia/decreased appeptite,
vomiting, diarrhea, blood in feces, dehydration, flatulence, increase borborygmi
Cats: Vomiting, diarrhea,
anorexia/decreased appetite, lethargy, hyper/acting strange, inappropriate
Storage: Store the powder and the
reconstituted product in the original carton, refrigerated at 2° to 8° C (36° to
46° F). Use the entire contents of the vial within 28 days of reconstitution.
PROTECT FROM LIGHT. After each use it is important to return the unused
portion back to the refrigerator in the original carton. As with other
cephalosporins, the color of the solution may vary from clear to amber at
reconstitution and may darken over time. If stored as recommended, solution
color does not adversely affect potency.
Federal (USA) law restricts this drug
to use by or on the order of a licensed veterinarian
How Supplied: CONVENIA is
available as a 10 mL multi-use vial containing 800 milligrams of cefovecin
as a lyophilized cake.
Pfizer Animal Health
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.