Canine Cognitive Dysfunction Syndrome
Pfizer Anipryl Tablets (Selegiline HCl) are for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine Pituitary Dependent Hyperadrenocorticism (PDH).
Anipryl Tablets can be prescribed by your veterinarian after a diagnosis
of CDS has been determined. Anipryl comes in a convenient tablet form for
easy dosing. Most dogs are prescribed one tablet each day, preferably in
the morning. (Anipryl can be given with food.) It's important to
administer every tablet as directed since interruption of therapy could
lead to the reappearance of signs.
Cognitive Dysfunction Syndrome
Cognitive Dysfunction Syndrome (CDS) is caused by physical
and chemical changes that affect the brain function in older dogs. Dogs with CDS
may show signs of confusion and/or various other behavioral changes that are not
a normal part of aging. This confusion can lead to a life of lonely isolation, separated from family
members who have come to cherish their older dog's companionship. This can be as
hard on family members as it is on the dog. Pet owners often describe their dogs
as less responsive, forgetful or confused.
Pet owners report that 69 to 75%
of dogs improved in at least one clinical sign after one month of Anipryl
therapy. Because CDS is a syndrome of multiple signs, no two dogs will
show exactly the same signs. Response to Anipryl may vary from dog to dog.
most common side effects are vomiting, diarrhea or changes in behavior such as
hyperactivity and restlessness. Most side effects are mild to moderate. Consult your veterinarian before using Anipryl with other
medications or with tick collars. As dogs grow older, they are likely to
experience more health problems. Senior dogs should be observed more closely
because changes in normal appearance, activity and behavior all can be signs
that veterinary attention may be needed.
Dosage and Administration:
- Cognitive Dysfunction Syndrome: Orally administer 0.5-1.0 mg/kg once
daily, preferably in the morning.
- Pituitary Dependent Hyperadrenocorticism: Orally administer 1 mg/kg once daily, preferably in the morning.
Anipryl is contraindicated in
patients with known hypersensitivity to this drug. In humans, selegiline is
contraindicated for use with meperidine and this contraindication is often
extended to other opioids.
Keep out of reach of children. Not
for human use.
- Anipryl should not be administered at doses
exceeding those recommended
- Avoid the combination of Anipryl and selective
serotonin reuptake inhibitors (e.g., fluoxetine) as well as Anipryl and
tricyclic (e.g., clomipramine, amitriptyline, imipramine) or other
- At least 14 days should elapse between
discontinuation of Anipryl and initiation of treatment with a tricyclic
antidepressant or selective serotonin reuptake inhibitor. Because of the long
half-life of fluoxetine and its active metabolites, at least 5 weeks should
elapse between discontinuation of fluoxetine and initiation of treatment with
Anipryl is not recommended for other
behavior problems such as aggression. In the clinical trials, 3 dogs showed an
increase in aggression while on this drug. The safety and efficacy of Anipryl
has not been evaluated in dogs with debilitating systemic diseases other than
The safety of Anipryl in breeding,
pregnant and lactating bitches, and breeding dogs has not been determined.
Adverse Reactions include restlessness/agitation,
vomiting, disorientation, diarrhea, diminished hearing, possible drug
interaction (weakness, confusion, incoordination and "seizure-like"
activity while being treated concurrently with metronidazole, prednisone, and
trimethoprim sulfa), increase in destructive behavior in a dog with separation
anxiety, anorexia, anemia, stiffness and polydipsia.
How Supplied: Five tablet strengths are available
in blister-packs of 30 tablets each: 2 mg, 5 mg, 10 mg, 15 mg, and 30 mg. Each
box contains 1 blister pack (30 tablets).
Storage: Store at controlled room temperature 20°-25°C