Clomipramine Hydrochloride Capsules
Clomipramine HCl is a tricyclic antidepressant FDA approved for veterinary use
in dogs for the treatment of separation anxiety. Clomipramine (Anafranil), FDA
approved for human use, is also used in veterinary medicine to treat aggression
and obsessive-compulsive disorders such as tail chasing. Clomipramine may also
be useful in cats, but cats tend to be more sensitive to tricyclic
Used in humans to treat anxiety and depression.
Action is by inhibition of serotonin uptake at presynaptic nerve terminals.
Beneficial effects may be caused primarily by blocking reuptake of serotonin.
The usual dose of clomipramine in dogs is 0.5-1.5mg per pound every 12-24 hours.
Give this medication with food.
When adjusting doses, initiate therapy with low dose and
increase gradually. There may be a 2-4 week delay before beneficial
effects are seen. After a favorable response is achieved, the dose can be
gradually lowered in some animals. In cats, doses of 1.25-2.5 mg/cat every
24 hours have been administered for psychogenic alopecia. Up to 5 mg/cat
every 24 hours has been used for treatment of urine spraying.
Side effects of
clomipramine may include drowsiness, dry mouth, rapid heart rate, loss of
appetite, vomiting and diarrhea. Some patients may become aggressive.
Do not use this medication in animals that are allergic to it or other tricyclic
antidepressants. Use with caution in patients with liver disease, urinary
retention, hyperthyroidism, seizure disorders or glaucoma. Do not use in
pregnant or nursing females. Do not use in breeding males. Do not use with
monoamine oxidase inhibitors (MAOIs) such as selegiline or Preventic tick
collar. If the patient is being given an MAOI, wait 2 weeks after discontinuing
before starting treatment with clomipramine. Do not use with other central
nervous system (CNS) depressants such as barbiturates or tranquilizers. Always
tell your veterinarian and pharmacist what other medications your pet is taking.
event of an overdose:
overdose may include convulsions, heart arrhythmia and rapid heart beat
(tachycardia). Contact your veterinarian in the case of an overdose.
Keep this medication in the container it came in, tightly closed. Store tablets
and capsules at room temperature, away from excess heat, light and moisture. Do
not store in the bathroom.
Keep medication out of the reach of children
Federal law restricts this product to use by or upon the order of a licensed veterinarian
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.