DL-Methionine Tablets, 500mg
DL-Methionine Tablets are for use as an aid in acidifying the urine of dogs and
cats. DL-Methionine is also an aid in controlling the odor from feline and
canine urine residues.
DL-Methionine tablets maybe used as a source of this
essential amino acid.
DL-Methionine may be used to
prevent the formation of magnesium ammonium phosphate crystals in the urine.
These crystals are commonly called struvite, Struvite is the most frequently
involved mineral in uroliths that occur in feline lower urinary tract disease
(LUTD) also known as feline urologic syndrome (FUS). Struvite crystals are more
soluble in acid urine and tend not to develop and will eventually dissolve as
urinary pH is reduced. Methionine is effective in increasing urine
LUTD (FUS) is relatively common and affects both sexes;
however, male cats are more frequently involved. Cystitis and urolithiasis
produce post-renal uremia with elevated blood urea nitrogen (BUN),
hyperphosphatemia, hyperkalemia, metabolic acidosis, and death if not treated.
The following principles have been suggested for
uroliths in LUTD that are predominantly composed of struvite to reduce the
concentration of pre-struvite crystalloids and formation of calculi.
- Reducing crystalloid concentration by reducing
dietary concentration of magnesium and phosphorus to minimal requirements.
- Increasing urinary volume by increasing water
- Increasing solubility of crystalloids by reducing
urinary pH and holding at a reduced value.
Adult cats: one tablet per 10 lbs body weight 1 or 2
times daily with food. Not intended for use in kittens.
Dogs: 1/2 tablet per 10 lbs body weight 1 or 2
times daily with food.
For urinary acidification in cats and dogs and
prevention of struvite urolithiasis urinary pH should be reduced to
approximately 6.0 - 6.6 and maintained in this range. Monitoring the pH of
freshly voided urine may be advisable.
Contraindications: Do not
administer to animals with severe liver, kidney or pancreatic disease, or those
which are acidotic due to conditions such as uncontrolled diabetes mellitus or
Storage: Keep tightly closed in a
cool, dry place at room temperature 59-86°F.