Diphenhydramine HCL 25mg
Diphenhydramine is an antihistamine used in the treatment of allergies, insect
bites or stings and other causes of itching. It is also used for its sedative
and antiemetic effects in the treatment of motion sickness and travel anxiety.
It is also used for its antitussive effect. Adult strength 50 mg is often
taken as a "Nighttime Sleep Aid". Compare to Compoz and Benedryl.
Diphenhydramine is a non-prescription (OTC) product available as 25mg and 50mg
tablets or capsules as well.
How this medicine should be used:
Diphenhydramine is FDA approved for external use in dogs and cats.
Diphenhydramine oral and injectable is not FDA approved for use in veterinary
medicine; however, it is a commonly accepted practice to use this medication in
dogs and cats. The usual dose in dogs and cats is 0.5-2mg/pound every 8-12
hours. The slow release capsule should not be mixed or dissolved in food. Do not
use diphenhydramine found in combination products containing sinus or cold
What are the side effects:
Side effects of diphenhydramine include drowsiness, dry mouth and urinary
retention. Rarely, vomiting and diarrhea can occur.
What special precautions are there:
Do not use this medication in animals that are allergic to it or other
antihistamines. Do not use in animals with glaucoma, prostate disease, urinary
obstruction, and high blood pressure. Do not use in pregnant or nursing animals.
Use with caution when given with other CNS depressant drugs such as
tranquilizers or barbiturates. Always tell your veterinarian and pharmacist what
other medications your pet is taking.
In the event of an overdose:
Contact your veterinarian or veterinary emergency room. Symptoms of overdose can
include seizures, extreme drowsiness, coma, respiratory depression and death.
How should I store this medication:
Keep this medication in the container it came in, tightly closed. Store this
medication at room temperature, away from excess heat, light and moisture. Do
not store in the bathroom. Throw away any medication that is outdated or no
Keep medication away from children and pets.
This information sheet is for educational purposes
only and is intended to be a supplement to, and not a substitute for, the
expertise and professional judgment of your veterinarian. The information is NOT
to be used for diagnosis or treatment of your pet. You should always consult
your own veterinarian for specific advice concerning the treatment of your pet.
The information is not intended to cover all possible uses, directions,
precautions, warnings, allergic reactions, drug interactions or adverse effects,
nor should it be construed to indicate that use of a particular drug is safe,
appropriate or effective for your pet. It is not a substitute for a veterinary
exam, and it does not replace the need for services provided by your
Adults and Children 12 years and older: one tablet at
Children under 12 years: ask a doctor
Dogs: 25-50 mg/dog, every 8 hours orally, or 2.2
mg/kg every 8-12 hours orally
Cats: 2-4 mg/kg, every 6-8 hours orally