Anthelmintic for Dogs
Drontal Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum
Anthelmintic Tablets - Bayer are indicated for removal of Tapeworms (Dipylidium
caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control
of Echinococcus multilocularis). For removal of Hookworms (Ancylostoma
caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris
leonina), and Whipworms (Trichuris vulpis) in dogs.
Drontal Plus Tablets are available in three sizes. Each size is scored for
convenient oral administration.
Plus Tablet for Puppies and Small Dogs contains 22.7 mg praziquantel, 22.7 mg
pyrantel base as pyrantel pamoate and 113.4 mg febantel per tablet.
Tablet for Medium Sized Dogs contains 68.0 mg praziquantel, 68.0 mg pyrantel
base as pyrantel pamoate and 340.2 mg febantel per tablet.
Tablet for Large Dogs contains 136.0 mg praziquantel, 136.0 mg pyrantel base as
pyrantel pamoate and 680.4 mg febantel per tablet.
Drontal Plus Tablets contain three active ingredients having
different modes of action and spectra of activity.
Praziquantel is active
against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver
and excreted in the bile. Upon entering the digestive tract from the bile,
cestocidal activity is exhibited. Following exposure to praziquantel,
the tapeworm loses its ability to resist digestion by the mammalian host.
Because of this, whole tapeworms, including the scolices, are very rarely passed
after administration of praziquantel. In many instances only disintegrated and
partially digested pieces of tapeworms will be seen in the stool. The majority
of tapeworms are digested and are not found in the feces.
Pyrantel pamoate is
active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic
receptors of the nematode resulting in spastic paralysis. Peristaltic action of
the intestinal tract then eliminates the parasite.
Febantel is active
against nematode parasites including whipworms. Febantel is rapidly absorbed and
metabolized in the animal. Available information suggests that the parasite's
energy metabolism is blocked, leading to energy exchange breakdown and inhibited
and clinical studies conducted with Drontal Plus Tablets demonstrate
that each of the three active ingredients act independently without
interference. The combined tablet formulation provides a wide spectrum of
activity against the indicated species of intestinal helminths.
Dosage and Directions:
The presence of parasites should be confirmed by laboratory fecal examination.
Weigh the animal before treatment. Administer the proper dosage as specified in
the following table as a single oral treatment.
Not for use in puppies less that 3 weeks of age or weighing less than 2 lbs.
Drontal Plus Tablets
for Puppies and Small Dogs
(2 - 25 lbs.)
Drontal Plus Tablets
for Medium Sized Dogs
(25 - 60 lbs.)
Drontal Plus Tablets
for Large Dogs
(45 lbs. and greater)
2 - 4
5 - 7
8 - 12
13 - 18
19 - 25
26 - 30
31 - 44
45 - 60
45 - 60
61 - 90
91 - 120
Drontal Plus Tablets have been developed for oral administration.
Tablets may be given directly by mouth or offered in a small amount of food.
Fasting is neither necessary nor recommended prior to or after treatment.
Retreatment: For those animals living where reinfections are likely to occur, clients should
be instructed in the steps to optimize prevention, otherwise, retreatment may be
necessary. This is true in cases of Dipylidium caninum where reinfection
is almost certain to occur if fleas are not removed from the animal and its
environment. In addition, for control of Echinococcus multilocularis, a
program of regular treatment every 21 to 26 days may be indicated.
multilocularis is a tapeworm species usually found in wild canids, including
foxes, coyotes and wolves. The parasite has also been identified in domestic
dogs and cats and is potentially a serious public health concern because it may
The adult tapeworm is
small (1-4mm) and resides in the intestinal tract of the definitive host (wild
or domestic canids). Eggs from the adult tapeworm are shed in the feces. Rodents
such as mice and voles serve as the intermediate host. Eggs ingested by rodents
develop in the liver, lungs and other organs to form multilocular cysts. The
life cycle is completed after a canid consumes a rodent infected with cysts.
Larvae within the cyst develop into adult tapeworms in the intestinal tract of
the canid. Eggs may be passed in the feces of the canid approximately 28 days
This parasite poses a
serious public health problem because of the possibility for human involvement
in the life cycle. If eggs shed by an infected canid are accidentally ingested,
a highly pathogenic condition (Alveolar Hydatid Disease) results from
development of the cyst stage in humans.
Domestic dogs living
in E. multilocularis endemic areas that roam freely with the opportunity
to catch wild rodents are at risk of infection. Pet owners should be advised on
how to minimize this risk. Proper restraint of dogs should be encouraged, along
with regular treatment with Drontal Plus Tablets, following the
dosing schedule aforementioned and precautions indicated below.
Contraindications: DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive
days with 3 times the labeled dosage rate) of the combination of febantel and
praziquantel in early pregnancy demonstrated an increased incidence of abortion
and fetal abnormalities. The effects of Drontal Plus on
pregnant animals have not been determined.
There are no known
contraindications against the use of praziquantel or pyrantel pamoate in dogs.KEEP OUT OF REACH OF CHILDREN.
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed
Drontal Plus Tablets should be
stored at controlled room temperatures between 59-86°F (15-30°C).
Each tablet size is available in bottles of 50 (puppies and small dogs, medium
sized dogs) or 30 (large dogs).
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.
*Special order, non-returnable