Nutramax Marin provides support for the liver with
silybin, the most active component of milk thistle in a more
bioavailable form, and
vitamin E. Silybin is the most biologically active component of an
extract known as silymarin. Silymarin/silypin has been shown to have
beneficial effects on liver function. Vitamin E, a membrane-associated
antioxidant, helps protect the liver against oxidant injury.
Silybin/silymarin has many different
mechanisms of action. In-vitro and in-vivo studies have shown that it
protects agains oxidative stress; promotes protein synthesis within
hepatocytes, a mechanism for liver cell regeneration; inhibits
leukotriene production, which can be beneficial as production of
leukotrienes is a component of the inflammatory response; stimulates
biliary flow and production of hepatoprotective bile salts (e.g. beta-muricholate
and ursodexycholate) and increases levels of glutathione.
Vitamin E, a memberate-associated antioxidant, benefits liver function
because oxidant damanage to hepatocytes can affect liver health. Vitamin
E has been shown to reduce the oxidative damage to the hepatocyte
mitochondrial membranes caused by hydrophobic bile salts (these bile
salts build up in the liver when bile flow is impaired) Vitamin E use
has been reported in dogs for its antioxidant role that also help to
support hepatic health.
Marin, Denosyl and Denamarin support the liver through differing
actions and may be used individually or in combination depending on your
pet's needs. Your veterinarian can advise you on the best way to support
your dog's liver.
Marin For Dogs is available as
chewable tablets that may be given orally or crumbled over the food.
Recommended administration amounts are provided below.
Tablets should be given on a
Store in a cool dry place. Keep
tablets in bottle until used.