Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment
Panolog Ointment - Fort Dodge
is a topical medication used to treat ear and skin disorders caused by infection or allergies. Panolog is particularly useful in the treatment of acute and chronic otitis, interdigital cysts and in treating anal gland
infections in dogs and cat.
Panolog Ointment is
also indicated in the management of dermatologic disorders characterized by
inflammation and dry or exudative dermatitis, particularly those caused,
complicated or threatened by bacterial or yeast infections. It is also of value in eczematous dermatitis, contact dermatitis
and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis
due to parasitic infestation.
Active Ingredients per ml:
- Nystatin 100,000 units
- Neomycin sulfate 2.5 mg
- Thiostrepton 2,500 units
- Triamcinolone acetonide 1.0 mg
The preparation is
intended for local therapy in a variety of cutaneous disorders of cats and
dogs; it is especially useful in disorders caused, complicated or threatened
by bacterial and/or candidal (monilial) infection.
By virtue of its
four active ingredients, Panolog Ointment provides four basic therapeutic
effects; anti-inflammatory, antipruritic, antifungal and antibacterial.
Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid
and prolonged symptomatic relief on topical administration. Inflammation,
edema and pruritus promptly subside and lesions are permitted to heal.
Nystatin is the first well-tolerated antifungal antibiotic of dependable
efficacy for the treatment of cutaneous infections caused by Candida
albicans (Monilia). Nystatin is fungistatic in vitro against a
variety of yeast and yeast-like fungi including many fungi pathogenic to
animals. No appreciable activity is exhibited against bacteria. Thiostrepton
has a high order of activity against gram-positive organisms, including many
which are resistant to other antibiotics: neomycin exerts antimicrobial
action against a wide range of gram-positive and gram-negative bacteria.
Together they provide comprehensive therapy against those organisms
responsible for most superficial bacterial infections.WARNINGS
experimental data have demonstrated that corticosteroids administered orally
or by injection to animals may induce the first stage of parturition if used
during the last trimester of pregnancy and may precipitate premature
parturition followed by dystocia, fetal death, retained placenta and
corticosteroids administered to dogs, rabbits and rodents during pregnancy
have resulted in cleft palate in offspring. Corticosteroids administered to
dogs during pregnancy have also resulted in other congenital anomalies
including deformed forelegs, phocomelia and anasarca.
Panolog Ointment (Nystatin-Neomycin
Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment USP) is not intended
for the treatment of deep abscesses or deep-seated infections such as
inflammation of the lymphatic vessels. Parenteral antibiotic therapy is
indicated in these infections.
has been extremely well tolerated. Cutaneous reactions attributable to its
use have been extremely rare. The occurrence of systemic reactions is rarely
a problem with topical administration. There is some evidence that
corticosteroids can be absorbed after topical application and cause systemic
effects. Therefore, an animal receiving Panolog Ointment therapy should be
observed closely for signs such as polydipsia, polyuria and increased weight
is not generally recommended for the treatment of deep or puncture wounds or
neomycin may occur. If redness, irritation, or swelling persists or
increases, discontinue use. Do not use if pus is present since the drug may
allow the infection to spread. Keep this and all medications out of the
reach of children.
Oral or parenteral use of corticosteroids, depending on dose, duration and
specific steroid, may result in inhibition of endogenous steroid production
following drug withdrawal.
SAP and SGPT (ALT)
enzyme elevations, polydipsia and polyuria have occurred following
parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting
and diarrhea (occasionally bloody) have been observed in dogs.
in dogs has been reported in association with prolonged or repeated steroid
therapy. Temporary hearing loss has been reported in conjunction with
treatment of otitis. However, regression usually occurred following
withdrawal of the drug. If hearing dysfunction is noted during the course of
treatment, discontinue use of Panolog Ointment.
any medication into the ear, examine the external ear canal thoroughly to be
certain the tympanic membrane is not ruptured in order to avoid the
possibility of transmitting infection to the middle ear as well as damaging
the cochlea or vestibular apparatus from prolonged contact. If hearing or
vestibular dysfunction is noted during the course of treatment, discontinue
use of Panolog Ointment.
administration is dependent on the severity of the condition. For mild
inflammations, application may range from once daily to once a week; for
severe conditions Panolog Ointment may be applied as often as two to three
times daily, if necessary. Frequency of treatment may be decreased as
Clean ear canal of impacted cerumen. Inspect canal and remove any foreign
bodies such as grass awns, ticks, etc. Instill three to five drops of
glands, cystic areas, etc.:
Drain gland or cyst and then fill with Panolog Ointment.
Clean affected areas, removing any encrusted discharge or exudate. Apply
Panolog Ointment sparingly in a thin film.
Federal law restricts this drug to
use by or on the order of a licensed veterinarian
is supplied in tubes of 7.5 mL, 15 mL, and 30 mL, each with an elongated tip for easy application, and in dispensing
packages of 8 fl. oz. (240 mL).
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.