(milbemycin oxime - lufenuron)
Novartis Sentinel Flavor Tabs are palatable once-a-month tablets that prevent
heartworm disease and flea populations in dogs and puppies. Sentinel Flavor Tabs also control flea populations
and adult hookworms, and remove and control adult roundworm and whipworm
infections in dogs and puppies.
Sentinel Flavor Tabs are available in four tablet sizes in
color-coded packages for oral administration to dogs and puppies according
to their weight. Each tablet is formulated to provide
a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound
(10 mg/kg) body weight of lufenuron.
SENTINEL Flavor Tabs are indicated for use in dogs and
puppies, four weeks of age and older, and two pounds body weight or greater.
SENTINEL Flavor Tabs are also indicated for the prevention of heartworm
disease caused by Dirofilaria immitis, for the
prevention and control of flea populations, the control of adult
Ancylostoma caninum (hookworm), and the removal and
control of adult Toxocara canis and
Toxascaris leonina (roundworm) and
Trichuris vulpis (whipworm) infections.
Lufenuron controls flea populations by preventing the
development of flea eggs and does not kill adult fleas. Concurrent use of an
adulticide product may be necessary for adequate control of adult fleas.
SENTINEL Flavor Tabs may be used concurrently with CAPSTAR
(nitenpyram) Tablets to provide a Flea Management System that kills adult
fleas and prevents flea eggs from hatching. Please see the Supplemental
Package Insert provided with this product for information about concurrent
use of the two products.
Without concurrent use of an adulticide,
adequate flea control may not be achieved in dogs that have repeated
exposure to flea infected animals or environments.
Do not use in puppies less than four weeks of age and less
than two pounds of body weight. Prior to administration of SENTINEL Flavor
Tabs, dogs should be tested for existing heartworm infections. Infected dogs
should be treated to remove adult heartworms and microfilariae prior to
initiating treatment with SENTINEL Flavor Tabs. Mild, transient
hypersensitivity reactions manifested as labored respiration, vomiting,
salivation and lethargy have been noted in some treated dogs carrying a high
number of circulating microfilariae. These reactions are presumably caused
by release of protein from dead or dying microfilariae.
SENTINEL Flavor Tabs immediately break the flea life cycle
by inhibiting egg development. However, pre-existing flea populations may
continue to develop and emerge after treatment with SENTINEL Flavor Tabs has
begun. Based on results of clinical studies, this emergence generally occurs
during the first 30-60 days. Therefore, noticeable control may not be
observed until several weeks after dosing when a pre-existing infestation is
present. Cooler geographic areas may have longer lag periods due to a
prolonged flea life cycle. The concurrent use of an approved adulticide,
like CAPSTAR may be employed depending on the severity of the infestation.
If a SENTINEL Flavor Tabs-treated dog comes in contact with
a flea-infested environment, adult fleas may infest the treated animal.
These adult fleas are unable to produce viable offspring. The temporary use
of an adulticide product may be necessary to kill these adult fleas.Dosage
SENTINEL Flavor Tabs are given orally, once a month, at the
recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and
4.55 mg/lb (10 mg/kg) lufenuron.
Administration: TO ENSURE ADEQUATE
ABSORPTION, ALWAYS ADMINISTER SENTINEL Flavor Tabs TO DOGS IMMEDIATELY AFTER
OR IN CONJUNCTION WITH A NORMAL MEAL.
Body Weight / Sentinel Size
- 2 to 10 lbs . . . 2.3 mg
- 11 to 25 lbs . . . 5.75 mg
- 26 to 50 lbs . . . 11.5 mg
- 51 to 100 lbs . . . 23.0 mg
- Dogs over 100 lbs - give the appropriate combination of tablets
SENTINEL Flavor Tabs are palatable and most dogs will
consume the tablet when offered by the owner. As an alternative to direct
dosing, the tablets can be hidden in food. Be certain the dog consumes the
entire tablet or tablets. Administer SENTINEL Flavor Tabs to dogs,
immediately after or in conjunction with a normal meal. Food is essential
for adequate absorption of lufenuron. Watch the dog closely following
administration to be sure the entire dose has been consumed. If it is not
entirely consumed, redose with the full recommended dose as soon as
SENTINEL Flavor Tabs must be administered monthly,
preferably on the same date each month. Treatment with SENTINEL Flavor Tabs
may begin at any time of year. In geographic areas where mosquitoes and
fleas are seasonal, the treatment schedule should begin one month prior to
the expected onset and should continue until the end of mosquito and flea
season In areas with year-round infestations, treatment should continue
through the entire year without interruption.
If a dose is missed and a 30-day interval between dosing is
exceeded, administer SENTINEL Flavor Tabs immediately and resume the monthly
dosing schedule. If SENTINEL Flavor Tabs replace daily diethylcarbamazine
(DEC) for heartworm prevention, the first dose must be given within 30 days
after the last dose of DEC.
Federal (USA) law restricts this drug to use by or on the
order of a licensed veterinarian.
The following adverse reactions have been reported in dogs
after giving milbemycin oxime or lufenuron: vomiting, depression/lethargy,
pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia,
convulsions, hypersalivation and weakness.
How Supplied: SENTINEL Flavor Tabs are
available in four tablet sizes, (see Dosage Section), formulated according
to the weight of the dog. Each tablet size is available in color-coded
packages of six and twelve tablets each, which are packaged 10 per display
Store in a dry place at controlled room temperature, between
59° and 86°F (15-30°C).