Dosage and Administration: For oral use in dogs and cats only.
The recommended dosage for oral
administration to dogs and cats is 1.25 mg marbofloxacin per lb of body
weight once daily, but the dosage may be safely increased to 2.5 mg/lb.
For the treatment of skin and soft tissue infections, Zeniquin
tablets should be given for 2-3 days beyond the cessation of clinical
signs for a maximum of 30 days. For the treatment of urinary tract
infections, Zeniquin tablets should be administered for at least 10
days. If no improvement is noted within 5 days, the diagnosis should be
re-evaluated and a different course of therapy considered.DRUG INTERACTIONS: Compounds [e.g., sucralfate, antacids, and
mineral supplements] containing divalent and trivalent cations [e.g.,
iron, aluminum, calcium, magnesium, and zinc] can interfere with the
absorption of quinolones which may result in a decrease in product
bioavailability. Therefore, the concomitant oral administration of
quinolones with foods, supplements, or other preparations containing
these compounds should be avoided.
CONTRAINDICATIONS: Marbofloxacin and other quinolones have
been shown to cause arthropathy in immature animals of most species
tested, the dog being particularly sensitive to this side effect.
Marbofloxacin is contraindicated in immature dogs during the rapid
growth phase [small and medium breeds up to 8 months of age, large
breeds up to 12 months of age and giant breeds up to 18 months of age]. Marbofloxacin is contraindicated in cats under 12 months of age.
Marbofloxacin is contraindicated in dogs and cats known to be
hypersensitive to quinolones.
PRECAUTIONS: Quinolones should be used with caution in animals
with known or suspected central nervous system [CNS] disorders. In such
animals, quinolones have, in rare instances, been associated with CNS
stimulation which may lead to convulsive seizures. Quinolones have been
shown to produce erosions of cartilage of weight-bearing joints and
other signs of arthropathy in immature animals of various species. The
use of fluoroquinolones in cats has been reported to adversely affect
the retina. Such products should be used with caution in cats. The
safety of marbofloxacin in animals used for breeding purposes, pregnant,
or lactating has not been demonstrated.
For use in animals only. Keep out of reach of
The following signs were reported in less than 1% of cases:
increased thirst, soft stool/diarrhea, behavioral changes,
shivering/shaking/tremors, and ataxia.
Federal law restricts this drug to use by or on the order of
a licensed veterinarian
HOW SUPPLIED: Marbofloxacin is supplied in 25-mg, 50-mg,
100-mg, and 200-mg scored, coated tablets.
Storage: Store below 30°C (86°F).
Pfizer Animal Health