Vitamin K-1 Injection (Phytonadione 10 mg/ml) by VetOne

For Animal Use Only

Active Ingredient: Phytonadione 10 mg/mL (Vitamin K-1)

Dosage Form: Sterile aqueous colloidal injectable solution

VetOne Vitamin K-1 Injection contains phytonadione, a synthetic form of vitamin K-1, used to treat and prevent coagulation disorders associated with vitamin K deficiency or interference with vitamin K activity. It is especially indicated for animals exposed to anticoagulant rodenticides or bishydroxycoumarin in spoiled or moldy sweet clover.

• Coagulation disorders due to faulty formation of factors II, VII, IX, and X caused by vitamin K deficiency or interference with vitamin K activity.
• Counteracting hypoprothrombinemia induced by ingestion of anticoagulant rodenticides.
• Counteracting hypoprothrombinemia caused by bishydroxycoumarin in spoiled or moldy sweet clover.
• Indicated for use in cattle, calves, horses, swine, sheep, goats, dogs, and cats.

Vitamin K-1 is essential for the hepatic production of active vitamin K–dependent clotting factors II, VII, IX, and X. It acts as a cofactor in the posttranslational carboxylation of specific glutamic acid residues, converting inactive precursors into active coagulation factors. In vitamin K–deficient animals, administration of phytonadione restores normal clotting function.

Following intramuscular administration, phytonadione is readily absorbed and initially concentrated in the liver. The onset of action after intravenous administration is generally detectable within 1–2 hours, with hemorrhage usually controlled within 3–6 hours. A normal prothrombin level may often be obtained within 12–14 hours.

Whenever possible, administer by the subcutaneous or intramuscular route. If intravenous administration is unavoidable, dilute and inject very slowly, not exceeding 1 mg per minute.

Vitamin K-1 Injection may be diluted with:

• 0.9% Sodium Chloride Injection
• 5% Dextrose Injection
• 5% Dextrose and Sodium Chloride Injection

Other diluents should not be used. Begin administration immediately after mixing with diluent and discard any unused portion of the dilution.

• Hypersensitivity to phytonadione or any component of the formulation.

• Drug interactions: Temporary resistance to prothrombin-depressing anticoagulants may occur, especially with larger doses of phytonadione. When reinstituting anticoagulant therapy, higher doses or an anticoagulant with a different mechanism (e.g., heparin sodium) may be required.
• Monitoring: Prothrombin time should be checked regularly as clinical conditions indicate.
• Parenteral products: Inspect visually for particulate matter and discoloration prior to administration whenever solution and container permit.
• In cases of shock or excessive blood loss, whole blood or component therapy may be indicated. This does not correct the underlying clotting factor deficiency, so Vitamin K-1 Injection should be given concurrently.

Store as directed by the manufacturer. Protect from light and use aseptic technique when withdrawing and administering the product.

For use in animals only. Always follow your veterinarian’s recommendations for dosing and monitoring, especially in cases of anticoagulant rodenticide exposure or severe hemorrhage.