Pancreatic Enzyme Replacement
Epizyme Powder for pets is a digestive pancreatic intestinal aid
used in replacement therapy where digestion of protein, carbohydrate and fat is
inadequate due to exocrine pancreatic insufficiency.
Pancreatitis is an important disease in the dog and
cat. Disease of the pancreas has been classified into 4 distinctive
categories; acute necrotic pancreatitis; subacute or chronic pancreatitis;
pancreatic fibrosis and collapse or atrophy of the acinar pancreatic tissue.
Only acute and chronic pancreatitis is readily recognized clinically.
Dogs that acquire acute pancreatitis usually
recover, but are subject to exacerbations of the chronic inflammatory
process that may persist. The acute lesion may not completely heal, and
progressive destruction of the gland may take place over a period of months,
even in the absence of clinical signs.
Chronic pancreatitis is characterized by acute
exacerbations of pancreatic inflammation that occur after the remission of
acute pancreatitis. Signs of the disease are similar to those of acute
pancreatitis but are usually less severe.
Steatorrhea, diarrhea, weight loss and increased
appetite characterize the digestive impairment caused by failure of the
pancreatic exocrine secretion. Secretion ceases when the acinar tissue is
destroyed in the course of chronic pancreatitis. This sequel does not become
evident until virtually total destruction of the acinar pancreas has
occurred, because as little as 12 to 20 percent of the exocrine pancreas can
secrete enough pancreatic juices to sustain digestion. Thus, digestive
impairment is a relatively late event in the pathogenesis of chronic
pancreatitis. Transient episodes of fetid diarrhea may occur at the time of
an acute exacerbation and may be caused by temporary reduction of pancreatic
exocrine secretion. However, food engorgement or the ingestion of fatty food
often precipitates an exacerbation of chronic pancreatitis and the character
of the food, rather than the absence of pancreatic enzymes, may cause the
The veterinarian should not be too concerned about
whether the pancreatic lesion is acute or chronic. His primary concern
should be to recognize pancreatic inflammatory disease and begin treatment.
The differentiation of acute and chronic pancreatitis is then made basis on
history, and is of importance in advancing the prognosis.
EPIZYME will replace pancreatic enzyme secretions
after total pancreatectomy.
Discontinue use in animals with symptoms of
Treatment in acute and chronic pancreatitis:
The most important aspect of the treatment of acute
pancreatitis is initiation of vigorous therapy aimed at combating pain and
shock, restoring blood volume, blood pressure and renal function, with
reduction of pancreatic secretions and combating secondary infection of
necrotic tissue. Animals surviving and acute attack should be placed on a
bland and easily digested diet and supplemented with EPIZYME.
In chronic pancreatitis, replacement therapy must be
given for the duration of the animal's life. Two to three feedings of a
bland and easily digested diet containing sufficient quantities of good
quality proteins and carbohydrates and low levels of fat are recommended.
EPIZYME is given with each meal at a dosage level sufficient to keep the
Dosage and administration:
EPIZYME powder is added to moistened dog food
(canned or dry). Thorough mixing is necessary to bring the enzymes into
close contact with the food particles. Allow this mixture to sit for five
minutes before feeding. Incubation at room temperature for 15-20 minutes
before feeding appears to enhance the digestive process. Frequent feeding,
at least 3 times daily is important.
Dogs 3/4-1 teaspoonful (2.8g teaspoonful) with each
Cats: 1/4-3/4 teaspoonful (2.8g teaspoonful) with
No one regimen will be successful for every patient.
The above dosage should be adjusted according to the severity of the
pancreatic exocrine deficient and the weight of the animal. In cases of
chronic insufficiency, the dosage should be increased until desired results
Dosage should be increased until desired results are
Each 2.8 grams (1 teaspoon) contains sufficient
pancreatic enzyme to digest (in vitro):
460 g starch
Each 2.8 grams (1 teaspoonful) of Powder contains:
- Lipase . . . 71,400 USP units
- Protease . . . 388,000 USP units
- Amylase . . . 460,000 USP units
Epizyme is activated whole raw pancreas; a pancreatic enzyme concentrate
of porcine origin containing standardized amylase, protease and lipase
activities plus esterases, peptidases, Nucleases and elastase. Not an
extract product and not enteric coated.
Epizyme Powder is offered in 4 oz, 8 oz and 12 oz sizes.
Storage: Keep tightly closed in a cool, dry
For use in Dogs and Cats only.
For animal use only.
Not for human use.
Made in U.S.A. Cruelty Free
Federal law restricts this drug to use by
or on the order of a licensed veterinarian
Rx Medication Sold Only To Licensed Veterinarians & Pharmacies. Current License Must Be On File Prior To Shipping.